Jardiance Empagliflozin Tablets

1. Indications and Usage
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
2. Dosage and Administration
Recommended Dosage: The recommended dose is 10 mg taken once daily in the morning, with or without food. In patients who tolerate this dose, the dose may be increased to 25 mg once daily.
Renal Function: Do not initiate if eGFR is below 45 mL/min/1.73 m².
3. Mechanism of Action
Empagliflozin selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the kidney. This inhibition reduces renal glucose reabsorption and lowers the renal threshold for glucose, thereby increasing urinary glucose excretion and lowering blood glucose levels.
4. Safety and Warnings
Hypersensitivity: Serious hypersensitivity reactions (e.g., angioedema, Stevens-Johnson syndrome) are contraindications.
Volume Depletion: Risk is increased with concurrent diuretic use, elderly patients, or renal impairment. Correct volume depletion before initiation.
Ketoacidosis: Skeletal DKA may occur; consider discontinuation during acute illness, fasting, or reduced caloric intake.
Renal Toxicity: Monitor for acute kidney injury and worsening renal function.
Infections: Increased risk of genital mycotic infections and urinary tract infections.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: the drug instructions of the drug regulatory authority show that adverse reactions include hypotension, ketoacidosis, acute kidney injury, urinary sepsis, genital fungal infection, etc.
Clinical Research: Clinical trials have demonstrated significant HbA1c reduction, body weight loss, and cardiovascular risk reduction.
6. Drug Interactions
Diuretics: Concomitant use may increase the risk of volume depletion.
Insulin and Sulfonylureas: May increase the risk of hypoglycemia.
Lithium: May antagonize serum lithium concentration.
Urine Glucose Tests: SGLT2 inhibitors interfere with urine-based glucose monitoring.
7. Pharmaceutical Information
Composition: Active ingredient is empagliflozin.
Appearance: Film-coated tablets; white to off-white.
Storage: Store at controlled room temperature in a tight, light-resistant container.