Weidimei Aluminium Magnesium Carbonate Tablets

1. Indications and Usage
Gastric and Duodenal Ulcers: Treatment of gastric and duodenal ulcers.
Gastritis: Management of chronic, acute, and erosive gastritis.
Reflux Esophagitis: Treatment of reflux esophagitis.
Symptomatic Relief: Alleviation of gastric discomfort associated with gastric acid, such as gastric pain, heartburn, acidic belching, and bloating.
Gastric Protection: Prevention of gastric mucosal damage caused by non-steroidal anti-inflammatory drugs (NSAIDs).
2. Dosage and Administration
Adults: Chew 1-2 tablets per dose, 3-4 times daily.
Timing: Usually taken 1-2 hours after meals, at bedtime, or when gastric discomfort occurs.
Special Populations: Dosage for children should be determined by a physician or pharmacist.
Precautions: Do not use continuously for more than 7 days. If symptoms do not improve, medical consultation is required.
3. Mechanism of Action
Antacid Effect: The compound rapidly and persistently neutralizes excess gastric acid.
Pepsin Inhibition: It inhibits the activity of pepsin, a major enzyme involved in mucosal damage.
Mucosal Protection: The drug continuously enhances the action of gastric mucosal protective factors, promoting mucosal repair.
4. Safety and Warnings
Renal Impairment: Patients with renal damage (creatinine clearance < 30 ml/min) should not take large doses for a long period.
Contraindications: Do not use in patients with severe cardiac or renal failure, hypermagnesemia, or hypercalcemia.
Hypersensitivity: Discontinue immediately if signs of allergy or anaphylaxis appear.
Special Populations: Use with caution in pregnant women during the first trimester and during lactation.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Occasional constipation, loose stools, dry mouth, and loss of appetite.
High-Dose Effects: Large doses may cause gastrointestinal discomfort and soft, pasty stools.
Clinical Research: Clinical studies have confirmed that Aluminium Magnesium Carbonate provides effective and durable relief of symptoms associated with acid-related gastric diseases.
6. Drug Interactions
Absorption Interference: The medication may bind with other drugs, affecting their absorption.
Specific Interactions: Tetracyclines, iron preparations, digoxin, deoxycholic acid, famotidine, ranitidine, cimetidine, coumarin derivatives, benzodiazepines, and isoniazid.
Management: Other medications should be taken 1-2 hours before or after the drug to avoid interaction.
Vitamin Absorption: Aluminum agents may bind to bile salts, reducing the absorption of fat-soluble vitamins, particularly Vitamin A.
7. Pharmaceutical Information
Active Ingredient: Aluminium Magnesium Carbonate.
Appearance: White or off-white tablets.
Storage: Store in a sealed container.
Stability: Do not use if the physical appearance or state of the tablets changes.