Changlining Clostridium butyricum Live Tablets

1. Indications and Usage
Intestinal Flora Imbalance: Indicated for the treatment of diarrhea, abdominal bloating, and dyspepsia caused by intestinal flora disorders.
Acute and Chronic Diarrhea: Used as an adjunctive therapy for acute infectious diarrhea and chronic diarrhea.
Pediatric Indications: Also indicated for diarrhea and intestinal flora imbalance in infants and children.
2. Dosage and Administration
Adults: The usual dosage is 2 to 4 tablets per dose, 3 times daily.
Children: The dosage is typically 1 tablet per dose, 3 times daily.
Administration: Tablets should be swallowed with warm water or lukewarm boiled water.
Antibiotic Timing: Should be taken at least 1 hour apart from antibiotic therapy to prevent the live bacteria from being killed.
3. Mechanism of Action
Butyric Acid Production: Clostridium butyricum produces butyric acid, which serves as a primary energy source for colonic epithelial cells, promoting the repair of the intestinal mucosal barrier.
Anaerobic Environment: As a strict anaerobe, it consumes oxygen in the gut, creating an environment that favors the growth of beneficial indigenous anaerobic bacteria.
Antagonistic Activity: It secretes bacteriocins that inhibit the proliferation of pathogenic bacteria such as Clostridium perfringens and Escherichia coli.
4. Safety and Warnings
Temperature Control: The drug contains live bacteria and must be taken with water below 40°C to prevent the death of viable spores.
Antibiotic Interaction: If antibiotic therapy is necessary, a significant time interval (at least 1 hour) should be maintained.
Hypersensitivity: Contraindicated in patients with known hypersensitivity to the drug or its excipients.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: The drug is generally well-tolerated. Occasionally, mild gastrointestinal symptoms such as abdominal discomfort or increased flatulence may occur.
Rare Effects: No serious adverse reactions have been commonly reported in clinical studies.
6. Drug Interactions
Antibiotics: Bactericidal and bacteriostatic antibiotics may inhibit the activity or kill the administered bacteria.
Adsorbents: Medications that adsorb toxins (e.g., activated charcoal, bismuth preparations) may reduce the efficacy of the probiotic if taken simultaneously.
Antiviral Agents: Some antiviral drugs may also affect the viability of the bacteria.
7. Pharmaceutical Information
Active Ingredient: Clostridium butyricum (live spores).
Strength: Typically 400 mg or 4.5×10⁸ CFU per tablet.
Appearance: Sugar-coated or film-coated tablets, removing the coating reveals white or slightly yellow powder.
Storage: Keep in a dry and cool place, protected from light and moisture.