Danshentongle Ampeptide and Zinc Sulfate Tablets

1. Indications and Usage
Muscle Mass Maintenance: Indicated for the prevention of muscle loss (sarcopenia) in older adults.
Nutritional Support: Used as a nutritional supplement for elderly individuals with poor appetite or inadequate protein intake.
Zinc Deficiency: Indicated for the prevention and treatment of zinc deficiency.
2. Dosage and Administration
Standard Dose: The usual dosage is one tablet once daily, taken orally after a meal.
Administration: Swallow the tablet whole with water. It can be taken concurrently with other medications, but spacing them out is often advisable.
3. Mechanism of Action
Ampeptide (Branched-Chain Amino Acids): Leucine, isoleucine, and valine stimulate the mTOR pathway, directly activating muscle protein synthesis and reducing muscle protein breakdown.
Zinc Sulfate: Zinc is an essential trace element that acts as a cofactor for numerous enzymes involved in protein synthesis, cell division, and immune function, supporting overall metabolic health.
4. Safety and Warnings
Renal/Hepatic Impairment: Patients with severe renal or hepatic dysfunction should use with caution, as amino acid and metal metabolism may be impaired.
Allergies: Do not use in patients with known hypersensitivity to the ingredients.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Gastrointestinal discomfort, nausea, abdominal pain, and diarrhea.
Other Effects: Some patients may experience dizziness or skin rash.
Clinical Findings: Clinical studies in the elderly have shown improvements in grip strength and skeletal muscle mass indices with regular supplementation.
6. Drug Interactions
Tetracyclines / Quinolones: Zinc can form chelates with these antibiotics, significantly reducing their absorption and efficacy. They should be spaced by at least 2 hours.
Penicillamine: Zinc may reduce the absorption of penicillamine.
Thiazide Diuretics: May increase zinc excretion, potentially reducing the supplement’s efficacy.
7. Pharmaceutical Information
Active Ingredients: Ampeptide (Branched-Chain Amino Acids) and Zinc Sulfate.
Strengths: Typically contains a specific ratio of amino acids and a defined amount of elemental zinc (e.g., 10–15 mg).
Appearance: Usually white or pale yellow tablets.
Storage: Store in a cool, dry place, protected from light and moisture.