Sanyu Bendazol Hydrochloride Tablets

1. Indications and Usage
Hypertension and Spasms: Indicated for mild hypertension, cerebrovascular spasm, and gastrointestinal smooth muscle spasm.
Neurological and Obstetric Uses: Also used for poliomyelitis sequelae, peripheral facial paralysis, and hypertensive syndrome in pregnancy.
2. Dosage and Administration
Hypertension and Gastrointestinal Spasms: The usual adult dosage is 10–20 mg (1–2 tablets) three times daily.
Neurological Disorders: The usual dosage is 5–10 mg (1/2–1 tablet) three times daily.
Administration: Orally administered with water.
3. Mechanism of Action
Vasodilation: Bendazol has a direct relaxing effect on vascular smooth muscle, reducing peripheral resistance and lowering blood pressure.
Antispasmodic Effect: It also relaxes gastrointestinal smooth muscle, providing relief from spasms.
CNS Stimulation: The drug can mildly excite the central nervous system.
4. Safety and Warnings
Hypotension Risk: Large doses can cause a significant drop in blood pressure.
Special Populations: Safety and efficacy in children, the elderly, pregnant, and breastfeeding women have not been fully established.
Contraindications: Contraindicated in patients with known hypersensitivity to the drug.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Large doses may cause increased sweating, facial flushing, mild headache, dizziness, nausea, and hypotension.
Monitoring: Patients should be monitored for excessive hypotension or signs of overdosage.
6. Drug Interactions
Interaction Profile: Specific drug interaction data for Bendazol Hydrochloride is currently not fully elucidated.
Precautions: Caution is advised when combining with other antihypertensive or vasodilating agents, as they may potentiate the hypotensive effects.
7. Pharmaceutical Information
Active Ingredient: Bendazol Hydrochloride (2-benzylbenzimidazole hydrochloride).
Strengths: Typically available as 10 mg tablets.
Appearance: White or off-white tablets.
Storage: Protect from light; store in a tight, dry container.