Xiannuoxin® is a domestically developed innovative drug. It is an oral anti-SARS-CoV-2 medicine. Simnotrelvir inhibits 3CL protease which is essential for coronavirus replication, while ritonavir slows down the metabolism of simnotrelvir to raise its plasma concentration and enhance antiviral activity.
Main Indications
For the treatment of adult patients with mild to moderate coronavirus disease 2019 (COVID-19).
Clinical Research
Phase 3 clinical studies demonstrated that simnotrelvir/ritonavir significantly shortens the time to symptom resolution and reduces viral load in COVID‑19 patients. The treatment showed good safety profile, and antiviral efficacy was observed when administered within 5 days of symptom onset.
Common Side Effects
Systemic reactions: dyslipidemia, elevated liver enzymes;
Common mild adverse reactions: nausea, diarrhea, vomiting, headache. Rare serious adverse events: hypersensitivity reactions.
Approval Status in China
This original innovative drug, marketed under brand name Xiannuoxin®, was conditionally approved for marketing in China in January 2023, with the specification of simnotrelvir 0.375g / ritonavir 0.1g. It is currently a prescription antiviral drug.
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