1. Indications and Usage
\nMantle Cell Lymphoma (MCL): Treatment of adult patients with MCL who have received at least one prior therapy .
\nChronic Lymphocytic Leukemia (CLL) \/ Small Lymphocytic Lymphoma (SLL): Treatment of adult patients with CLL or SLL .
\n2. Dosage and Administration
\nAdministration: Oral administration. Capsules must be swallowed whole with water. Do not chew, open, or crush the capsule.
\nFood Requirement: Can be taken with or without food .
\nStandard Dose:
\nRecommended Dose: 100 mg twice daily (approximately every 12 hours) .
\nMissed Dose: If a dose is missed, take it as soon as possible unless it is within 3 hours of the next scheduled dose. Do not make up for the missed dose .
\nDose Modification: Interrupt treatment or reduce dose for toxicities such as severe neutropenia, thrombocytopenia, or bleeding .
\n3. Mechanism of Action
\nAcalabrutinib is a potent, selective, oral small-molecule inhibitor of Bruton’s tyrosine kinase (BTK).
\nIt covalently binds to the cysteine residue in the ATP-binding site of BTK, inhibiting BTK enzymatic activity.
\nBTK is an essential signaling molecule in the B-cell antigen receptor (BCR) pathway.
\nBy blocking this pathway, acalabrutinib inhibits B-cell proliferation and tumor growth .
\n4. Safety and Warnings
\nHemorrhage: Serious and fatal hemorrhagic events can occur. Monitor for signs of bleeding. Interrupt therapy for 3\u20137 days prior to major surgery .
\nAtrial Fibrillation: Acalabrutinib can cause atrial fibrillation. Monitor for palpitations, dizziness, or syncope and manage accordingly .
\nInfections: Serious and fatal infections can occur. Monitor for signs of infection (e.g., fever, chills) and treat promptly .
\nCytopenias: Severe neutropenia and thrombocytopenia may occur. Monitor Complete Blood Counts (CBC) regularly .
\n5. Adverse Reactions
\nCommon adverse reactions (incidence \u226520%) include:
\nHeadache, Diarrhea.
\nFatigue, Asthenia, Pyrexia.
\nMusculoskeletal pain (e.g., arthralgia, myalgia).
\nHemorrhagic events (e.g., bruising, petechiae, epistaxis).
\nNausea, Rash.
\nNeutropenia, Thrombocytopenia, Anemia .
\n6. Drug Interactions
\nCYP3A Inhibitors: Avoid co-administration with strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) as they increase Acalabrutinib exposure. If unavoidable, reduce dose to 100 mg once daily .
\nCYP3A Inducers: Avoid co-administration with strong CYP3A inducers (e.g., rifampin) as they reduce efficacy .
\nAcid-Reducing Agents:
\nPPIs: Avoid co-administration with Proton Pump Inhibitors (e.g., omeprazole) as they may significantly reduce solubility.
\nH2 Blockers\/Antacids: Separate administration by 2 hours .
\n7. Pharmaceutical Information
\nChemical Name: 2-(3,3-difluoro-1-(4-fluorophenyl)cyclobutylamino)-N-(6-oxo-5,6-dihydro-1,6-naphthyridin-3-yl)pyridine-3-carboxamide .
\nMolecular Formula: C22H20F3N5O2 .
\nStorage: Store at 20\u00b0C to 25\u00b0C (68\u00b0F to 77\u00b0F); excursions permitted to 15\u00b0C to 30\u00b0C (59\u00b0F to 86\u00b0F) .<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u5eb7\u53ef\u671f \u00ae(Calquence\u00ae)
\nGeneric Name: Acalabrutinib
\nStrength: 100 mg per capsule; 8 capsules per blister, 7 blisters per box (total 56 capsules\/box)
\nManufacturer: AstraZeneca AB
\nMarketing Authorization Holder: AstraZeneca AB; Domestic agent: AstraZeneca Investment (China) Co., Ltd.
\nApproval Date in China: March 23, 2023
\nRegistration Number: \u56fd\u836f\u51c6\u5b57HJ20233138
\nStorage: Store at 20\u00b0C\u201325\u00b0C, brief transportation between 15\u00b0C\u201330\u00b0C is permitted; keep sealed, protected from light and moisture, keep away from children<\/p>\n
Price&Cost:Contact Us now for the best price of Acalabrutinib\uff08Calquence\uff09<\/p>\n","protected":false},"featured_media":2862,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[75],"product_cat":[26],"product_tag":[],"class_list":["post-2861","product","type-product","status-publish","has-post-thumbnail","product_brand-astrazeneca","product_cat-capsules","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n