1. Indications and Usage
\nLocally Advanced Basal Cell Carcinoma (laBCC): Treatment of adult patients with laBCC who have relapsed after surgery or radiation therapy, or who are not candidates for surgery or radiation therapy\u3002
\n2. Dosage and Administration
\nAdministration: Oral administration. Swallow capsules whole with water. Do not cut, crush, or chew the capsules\u3002
\nFood Requirement: Must be taken on an empty stomach. Take at least 1 hour before or 2 hours after a meal. Food significantly increases drug exposure and toxicity risk\u3002
\nStandard Dose:
\nRecommended Dose: 200 mg once daily until disease progression or unacceptable toxicity\u3002
\nMissed Dose or Vomiting: If a dose is missed or vomiting occurs, skip the missed dose and resume the next dose at the scheduled time the following day. Do not double dose\u3002
\nDose Reduction: Dose reduction (e.g., to 100 mg or 200 mg every other day) or interruption is required for severe toxicities, particularly muscle injury or CK elevation\u3002
\n3. Mechanism of Action
\nSonidegib is a selective inhibitor of the Hedgehog (Hh) signaling pathway.
\nIt binds to and inhibits the transmembrane protein Smoothened (SMO), a key component of the Hh pathway.
\nBy blocking SMO, sonidegib prevents the activation of Gli transcription factors, thereby inhibiting tumor cell proliferation and growth in Hh pathway-driven cancers\u3002
\n4. Safety and Warnings
\nEmbryo-Fetal Toxicity: May cause severe birth defects or fetal death. Pregnancy testing is required before initiation. Females must use contraception during treatment and for 20 months after the final dose; males must use contraception during treatment and for 8 months after the final dose\u3002
\nMuscle Injury: Can cause severe muscle injury (rhabdomyolysis). Monitor Creatine Kinase (CK) levels periodically. Withhold or discontinue for CK elevation or muscle symptoms\u3002
\nHepatotoxicity: Monitor liver function tests (ALT, AST) regularly\u3002
\nBlood\/Sperm Donation: Patients should not donate blood for 20 months and sperm for 8 months after the last dose\u3002
\n5. Adverse Reactions
\nCommon adverse reactions (incidence \u226510%) include:
\nMusculoskeletal: Muscle spasms, musculoskeletal pain, myalgia\u3002
\nGeneral: Fatigue, pyrexia\u3002
\nDermatologic: Alopecia (hair loss), pruritus\u3002
\nGastrointestinal: Nausea, diarrhea, dyspepsia, abdominal pain, vomiting\u3002
\nNeurologic: Dysgeusia (taste disturbance), headache\u3002
\nLaboratory Abnormalities: Increased CK, increased creatinine, anemia\u3002
\n6. Drug Interactions
\nCYP3A Inhibitors: Avoid co-administration with strong CYP3A inhibitors (e.g., ketoconazole). Avoid moderate CYP3A inhibitors unless use is <14 days with close monitoring\u3002
\nCYP3A Inducers: Avoid co-administration with strong or moderate CYP3A inducers (e.g., rifampin, carbamazepine) as they reduce efficacy\u3002
\nDietary Interactions: Avoid grapefruit or grapefruit juice\u3002
\n7. Pharmaceutical Information
\nChemical Name: N-[6-(cis-2,6-Dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4′-(trifluoromethoxy)[1,1′-biphenyl]-3 carboxamide diphosphate\u3002
\nMolecular Formula: C25H25F3N3O3 \u00b7 2H3PO4\u3002
\nStorage: Store at 20\u00b0C to 25\u00b0C (68\u00b0F to 77\u00b0F); excursions permitted to 15\u00b0C to 30\u00b0C (59\u00b0F to 86\u00b0F)\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u5965\u6614\u6735\u00ae (Odomzo\u00ae)
\nGeneric Name: Sonidegib Phosphate
\nStrength: 200 mg per capsule, 30 capsules per box
\nManufacturer: Patheon Inc.
\nMarketing Authorization Holder: Sun Pharma Global FZE\uff1b\u56fd\u5185\u5546\u4e1a\u5316\uff1a\u6d4e\u6c11\u53ef\u4fe1\u96c6\u56e2
\nApproval Date in China: July 20, 2021
\nRegistration Number: \u56fd\u836f\u51c6\u5b57HJ20210061
\nStorage: Sealed, protected from light, stored below 25\u2103; keep away from moisture and out of sight and reach of children<\/p>\n
Price&Cost:Contact Us now for the best price of Sonidegib Phosphate\uff08Odomzo\uff09<\/p>\n","protected":false},"featured_media":2885,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[26],"product_tag":[],"class_list":["post-2884","product","type-product","status-publish","has-post-thumbnail","product_cat-capsules","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n