1. Indications and Usage
\nRelapsing Forms of Multiple Sclerosis (RMS): Treatment of patients (adults and pediatric patients 10 years of age and older) with relapsing forms of multiple sclerosis, to delay the accumulation of physical disability and reduce the frequency of clinical exacerbations .
\n2. Dosage and Administration
\nAdministration: Oral administration. Capsules should be swallowed whole with water. Can be taken with or without food .
\nStandard Dose:
\nRecommended Dose: 0.5 mg once daily .
\nDose Limit: Increasing the dose to 1.25 mg does not provide additional efficacy and is associated with a higher incidence of adverse reactions .
\nFirst-Dose Monitoring: Due to the risk of bradycardia and atrioventricular (AV) block, patients require monitoring for at least 6 hours after the first dose. Baseline ECG is required prior to dosing .
\n3. Mechanism of Action
\nFingolimod is a sphingosine 1-phosphate (S1P) receptor modulator.
\nIt binds to S1P receptors on lymphocytes, causing internalization of the receptor. This prevents lymphocytes from egressing from lymph nodes into the blood and CNS, thereby reducing inflammation and autoimmune damage in the CNS .
\n4. Safety and Warnings
\nBradycardia and AV Block: Can cause a transient decrease in heart rate and AV block. Baseline ECG is mandatory. First-dose monitoring is required for all patients .
\nMacular Edema: May cause macular edema. A comprehensive eye exam is recommended prior to treatment and 3-4 months after initiation .
\nInfections: May increase the risk of infections (e.g., herpes virus, respiratory infections). Do not initiate in patients with active acute or chronic infections .
\nHepatotoxicity: Monitor liver enzymes (ALT, AST) regularly. Discontinue if severe liver injury occurs .
\nFetal Toxicity: May cause fetal harm. Pregnancy is contraindicated. Contraception is required during treatment and for at least 2 months after discontinuation .
\n5. Adverse Reactions
\nCommon adverse reactions (incidence \u226510%) include:
\nInfections: Headache, influenza, nasopharyngitis.
\nGastrointestinal: Diarrhea.
\nMusculoskeletal: Back pain, pain in extremities.
\nLaboratory Abnormalities: Increased liver enzymes (ALT, AST), decreased lymphocyte count .
\n6. Drug Interactions
\nAntiarrhythmic Drugs: Concomitant use with Class Ia (e.g., quinidine) or Class III (e.g., dofetilide) antiarrhythmics is contraindicated due to risk of fatal arrhythmias .
\nCYP3A Inhibitors: Co-administration with strong CYP3A inhibitors (e.g., ketoconazole) increases Fingolimod exposure; caution is advised .
\nVaccines: Avoid live attenuated vaccines during treatment and for 2 months after discontinuation .
\n7. Pharmaceutical Information
\nChemical Name: (2S)-2-[2-(4-octylphenyl)ethyl]-1-amino-1,3-propanediol hydrochloride .
\nMolecular Formula: C19H33NO2 \u00b7 HCl .
\nStorage: Store at 20\u00b0C to 25\u00b0C (68\u00b0F to 77\u00b0F); excursions permitted to 15\u00b0C to 30\u00b0C (59\u00b0F to 86\u00b0F) .<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u6377\u7075\u4e9a\u00ae (Gilenya\u00ae)
\nGeneric Name: Fingolimod Hydrochloride
\nStrength: 0.5 mg per capsule, 14 capsules per blister, 2 blisters per box
\nManufacturer: Novartis Pharma Stein AG
\nMarketing Authorization Holder: Novartis Pharma AG\uff1b\u5883\u5185\u8d23\u4efb\u4eba\uff1a\u8bfa\u534e\u5236\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8
\nApproval Date in China: July 20, 2019
\nRegistration Number: \u56fd\u836f\u51c6\u5b57J20190024
\nStorage: Store sealed at 25\u2103 or below; short-term transportation between 15\u2103\u201330\u2103 is allowed, protect from light and moisture, keep out of reach of children<\/p>\n
Price&Cost:Contact Us now for the best price of Fingolimod Hydrochloride\uff08Gilenya\uff09<\/span><\/p>\n","protected":false},"featured_media":2899,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[80],"product_cat":[26],"product_tag":[],"class_list":["post-2897","product","type-product","status-publish","has-post-thumbnail","product_brand-novartis","product_cat-capsules","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n