1. Indications and Usage
\nMultidrug-Resistant Tuberculosis (MDR-TB):
\nIndicated as part of an appropriate combination regimen for the treatment of adult patients with multidrug-resistant pulmonary tuberculosis (MDR-TB) for whom an effective treatment regimen cannot otherwise be composed due to drug resistance or intolerance.
\n2. Dosage and Administration
\nAdministration: Oral administration. Must be taken with food to enhance bioavailability. Tablets should be swallowed whole with water.
\nDosing (Adults):
\nRecommended Dose: 100 mg twice daily.
\nDuration: Continuous treatment for 24 weeks.
\nDose Adjustment:
\nHepatic Impairment: No adjustment for mild impairment. Not recommended for moderate to severe impairment.
\nRenal Impairment: No adjustment for mild to moderate impairment. Not recommended for severe impairment due to lack of data.
\nHypokalemia\/Hypomagnesemia: Correct electrolyte imbalances before initiation.
\n3. Mechanism of Action
\nNitro-imidazo-oxazole Derivative: Delamanid is a novel antimycobacterial agent.
\nPathway: It inhibits the synthesis of methoxy- and keto-mycolic acids, which are essential components of the mycobacterial cell wall.
\nActivation: The drug is activated by deazaflavin-dependent N(5)-oxidoreductase (F420) in Mycobacterium tuberculosis.
\nPhysiological Effect: Disruption of cell wall synthesis leads to bacterial cell death. It shows no cross-resistance with currently used anti-tuberculosis drugs.
\n4. Safety and Warnings
\nQTc Prolongation: Delamanid causes QT interval prolongation. It is contraindicated in patients with QTc > 450 ms. Baseline and periodic ECG monitoring is required.
\nHepatotoxicity: Elevations in liver enzymes can occur. Monitor liver function tests (ALT, AST) before and during treatment.
\nSerum Albumin: Delamanid is highly bound to albumin. Use is contraindicated in patients with serum albumin < 2.8 g\/dL due to increased risk of QTc prolongation.
\nPregnancy and Lactation: Contraindicated in pregnant women and women of childbearing potential not using contraception.
\n5. Adverse Reactions
\nMost Common: Nausea, vomiting, headache, insomnia, dizziness, nausea, and diarrhea.
\nLaboratory Abnormalities: Hypokalemia, hypomagnesemia, anemia, leukopenia, and increased hepatic enzymes.
\n6. Drug Interactions
\nCYP3A4 Inducers: Contraindicated with strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, phenobarbital) as they significantly reduce delamanid plasma concentrations.
\nQTc-Prolonging Drugs: Caution advised with other drugs known to prolong QTc interval (e.g., fluoroquinolones, amiodarone). Frequent ECG monitoring is recommended.
\nCYP3A4 Inhibitors: Delamanid is not a significant inhibitor or substrate of CYP3A4, but interactions via plasma protein binding displacement may occur.
\n7. Pharmaceutical Information
\nChemical Name: (2R)-2-methyl-6-nitro-2-[(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)methyl]-2,3-dihydroimidazo<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u5fb7\u5c14\u5df4 \u00ae(Deltyba\u00ae)
\nGeneric Name: Delamanid
\nStrength: 50 mg per film-coated tablet, 60 tablets per box
\nManufacturer: Otsuka Pharmaceutical Co.,Ltd. Tokushima Itano Factory
\nMarketing Authorization Holder: \u6d59\u6c5f\u5927\u51a2\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u5927\u51a2\u5236\u836f\u4e2d\u56fd\u4e3b\u4f53\uff09
\nApproval Date in China: March 23, 2018
\nRegistration Number: \u56fd\u836f\u51c6\u5b57 HJ20180004\uff08\u8fdb\u53e3\u5c0f\u5305\u88c5\uff09\uff1b\u56fd\u836f\u51c6\u5b57 HJ20181244\uff08\u8fdb\u53e3\u5927\u5305\u88c5\uff09
\nStorage: Seal tightly, protect from light, store at temperature not exceeding 30\u2103; keep out of sight and reach of children<\/p>\n
Price&Cost:Contact Us now for the best price of Delamanid\uff08Deltyba\uff09<\/p>\n","protected":false},"featured_media":3089,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[27],"product_tag":[],"class_list":["post-3088","product","type-product","status-publish","has-post-thumbnail","product_cat-tablets","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n