1. Indications and Usage
\nChronic Hepatitis B:
\nIndicated for the treatment of patients with chronic hepatitis B.
\nImmuno-adjuvant for Vaccines:
\nIndicated as an immunoadjuvant for vaccination in immunocompromised individuals. It enhances the immune response to viral vaccines (e.g., influenza or hepatitis B vaccines) in patients with suppressed immune systems, including those on chronic hemodialysis and elderly patients.
\n2. Dosage and Administration
\nReconstitution and Administration:
\nDissolve each vial (1.6 mg) with 1 mL of Sterile Water for Injection immediately before use.
\nAdminister by subcutaneous injection.
\nContraindicated Routes: Do not administer via intramuscular (IM) or intravenous (IV) injection.
\nRecommended Dosage:
\nFor Chronic Hepatitis B: 1.6 mg twice weekly, with doses 3\u20134 days apart. Treatment should be continuous for 6 months (total of 52 injections) without interruption.
\nFor Vaccine Immune Response Enhancement: 1.6 mg twice weekly, with doses 3\u20134 days apart. Administer for 4 consecutive weeks (total of 8 injections). The first injection should be given immediately after vaccination.
\n3. Mechanism of Action
\nImmunomodulator:
\nThymalfasin (Thymosin alpha-1) is a synthetic 28 amino acid peptide.
\nPhysiological Effect:
\nIt promotes the maturation of T lymphocytes and increases the production of lymphokines (such as Interferon-alpha, Interferon-gamma, Interleukin-2, and Interleukin-3) and the expression of lymphokine receptors on T cells following antigen or mitogen activation. It also enhances the cytotoxicity of Natural Killer (NK) cells.
\n4. Safety and Warnings
\nHepatotoxicity Monitoring:
\nWhen used for chronic hepatitis B, liver function tests (ALT, albumin, and bilirubin) should be evaluated regularly. HBsAg, HBeAg, and HBV-DNA should be tested after treatment completion.
\nALT Fluctuation:
\nA transient elevation of ALT levels (up to twice the baseline) may occur during treatment. Therapy should generally continue unless there are signs of hepatic decompensation or failure.
\n5. Adverse Reactions
\nTolerability:
\nThymalfasin is generally well tolerated.
\nMost Common:
\nInjection site pain or discomfort.
\nRare Reactions:
\nErythema, transient muscle atrophy, polyarthralgia with edema, and rash are extremely rare.
\n6. Drug Interactions
\nCombination Therapy:
\nThymalfasin can be used in combination with Interferon-alpha to improve immune response.
\nInjection Precautions:
\nThe drug should be used with caution in combination with other medications and must not be mixed with other drugs in the same syringe for injection.
\n7. Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Thymalfasin (Thymosin alpha-1).
\nExcipients: Mannitol, Disodium Hydrogen Phosphate, Sodium Dihydrogen Phosphate.
\nStorage:
\nStore in the original package, protected from light, at 2\u00b0C to 8\u00b0C (refrigerated). Do not freeze.<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u65e5\u8fbe\u4ed9 \u00ae(Zadaxin\u00ae\uff09
\nGeneric Name: Thymalfasin
\nStrength: 1.6mg per vial, 2 vials per box, attached with 2 ampoules of 1mL Sterile Water for Injection
\nManufacturer: Patheon Italia S.p.A.
\nMarketing Authorization Holder: SciClone Pharmaceuticals\uff08\u8d5b\u751f\u836f\u4e1a\uff09\uff0c\u4e2d\u56fd\u5883\u5185\u8fd0\u8425\u4e3b\u4f53\uff1a\u8d5b\u751f\u836f\u4e1a\u63a7\u80a1\u6709\u9650\u516c\u53f8
\nApproval Date in China: Initial domestic approval year 1999\uff0cthe current registration certificate was approved in 2017
\nRegistration Number: \u56fd\u836f\u51c6\u5b57 HJ20171177
\nStorage: Sealed, protected from light, stored at 2\u2103\uff5e8\u2103 refrigeration; use immediately after reconstitution, keep out of reach of children<\/p>\n
Price&Cost:Contact Us now for the best price of Thymalfasin(Zadaxin)<\/p>\n","protected":false},"featured_media":3265,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25],"product_tag":[],"class_list":["post-3263","product","type-product","status-publish","has-post-thumbnail","product_cat-injection","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n