1. Indications and Usage
\nGlycemic Control in Type 2 Diabetes:
\nIndicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
\nLimitations of Use:
\nNot indicated for use in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Subcutaneous Injection ONLY. Administer once daily, at any time within 1 hour before a meal.
\nRecommended Dosage:
\nInitial Dose: 10 mcg once daily for the first 14 days to minimize gastrointestinal side effects.
\nMaintenance Dose: After 14 days, increase the dose to 20 mcg once daily.
\nAdministration Instructions:
\nIf a dose is missed, it should be administered within 1 hour before the next meal. If the patient does not remember within 1 hour before the meal, the dose should be skipped, and the regular schedule resumed the next day.
\n3. Mechanism of Action
\nGLP-1 Receptor Agonist:
\nLixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that activates the GLP-1 receptor.
\nGlucose-Dependent Insulin Secretion:
\nIt stimulates glucose-dependent insulin secretion and suppresses glucagon secretion.
\nDelayed Gastric Emptying:
\nIt significantly delays gastric emptying, which is particularly effective in reducing postprandial (after-meal) glucose excursions.
\n4. Safety and Warnings
\nAcute Pancreatitis:
\nMonitor for signs and symptoms of pancreatitis (e.g., persistent severe abdominal pain). Discontinue promptly if suspected.
\nHypoglycemia:
\nThe risk of hypoglycemia is increased when lixisenatide is used concomitantly with a sulfonylurea or insulin. Consider reducing the dose of the sulfonylurea or insulin.
\nRenal Impairment:
\nGastrointestinal adverse reactions (nausea, vomiting, diarrhea) may lead to dehydration and subsequent acute renal failure. Caution is advised in patients with renal impairment.
\nImmunogenicity:
\nPatients may develop anti-lixisenatide antibodies. The clinical significance is not fully established.
\n5. Adverse Reactions
\nMost Common:
\nHypoglycemia (especially with sulfonylurea), nausea, vomiting, diarrhea, headache, dizziness, and fatigue.
\nGastrointestinal Events:
\nGastrointestinal adverse reactions are the most frequent side effects, occurring primarily during the dose-escalation phase (first 2-3 weeks) and generally decreasing over time.
\n6. Drug Interactions
\nOral Medications:
\nDue to delayed gastric emptying, lixisenatide may impact the absorption of concomitantly administered oral medications.
\nNarrow Therapeutic Index Drugs: Caution is advised for drugs like warfarin or drugs requiring rapid absorption.
\nOral Contraceptives: Administer oral contraceptives at least 1 hour before or 11 hours after lixisenatide injection to ensure adequate absorption.
\nAcetaminophen (Paracetamol): Used as a marker drug in studies; absorption is delayed, though total exposure (AUC) is generally unchanged.
\n7. Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Lixisenatide (recombinant human GLP-1 analog).
\nAvailable Strengths: Prefilled pens (e.g., 10 mcg\/0.2 mL and 20 mcg\/0.3 mL).
\nStorage:
\nStore in a refrigerator at 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F). Do not freeze. In-use pens may be stored at room temperature (below 30\u00b0C\/86\u00b0F) for up to 28 days.<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u5229\u65f6\u654f\u00ae\uff08Adlyxin\u00ae\uff09
\nGeneric Name: Lixisenatide
\nStrength: 20\u03bcg per single dose, 1 pre-filled pen (14 doses)\/box
\nManufacturer: Sanofi-Aventis Deutschland GmbH (Germany); Sub-packager: Sanofi (Beijing) Pharmaceutical Co., Ltd.
\nMarketing Authorization Holder: Sanofi Winthrop Industrie
\nApproval Date in China: February 07, 2018
\nRegistration Number: \u56fd\u836f\u51c6\u5b57 J20180020
\nStorage: Unused pens store at 2\u2103\uff5e8\u2103, avoid freezing and light; after first use, store below 30\u2103, cap the pen for shading, do not store with needle attached; keep away from children<\/p>\n
Price&Cost:Contact Us now for the best price of Lixisenatide \uff08Adlyxin\uff09<\/p>\n","protected":false},"featured_media":3539,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[77],"product_cat":[25],"product_tag":[],"class_list":["post-3538","product","type-product","status-publish","has-post-thumbnail","product_brand-sanofi","product_cat-injection","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n