1. Indications and Usage
\nOsteoarthritis (OA) of the Knee:
\nTreatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen, NSAIDs).
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Intra-articular Injection ONLY (must be injected directly into the joint space).
\nNote: Strict aseptic technique is required.
\nRecommended Dosage:
\nStandard Course: One injection (typically 3 mL containing 60 mg of hyaluronate) once weekly for 3 consecutive weeks.
\nAlternative Regimen: Depending on the specific brand formulation, a single injection regimen may be approved if clinically indicated.
\nAdministration:
\nEnsure the needle is within the joint cavity before injecting.
\nIf there is significant joint effusion (fluid accumulation), aspiration of the fluid should be performed prior to injection.
\n3. Mechanism of Action
\nViscosupplementation:
\nThe drug acts as a temporary substitute and supplement for natural synovial fluid.
\nBDDE Cross-linking Technology:
\nUnlike non-crosslinked HA which is rapidly degraded by hyaluronidase in the joint, BDDE creates chemical bonds between HA molecules to form a 3D network structure.
\nBenefit: This significantly increases resistance to enzymatic degradation, prolonging the residence time and half-life of the drug within the joint cavity.
\nTherapeutic Effects:
\nRestores the viscoelasticity of the synovial fluid, providing lubrication to reduce friction, cushioning mechanical shock, and suppressing inflammatory mediators to relieve pain.
\n4. Safety and Warnings
\nContraindications:
\nPatients with a known hypersensitivity to hyaluronan preparations or any excipients.
\nPatients with intra-articular infections or skin diseases\/infections at the injection site.
\nWarnings:
\nAseptic Technique: Failure to use strict sterile technique may result in serious intra-articular infection (septic arthritis).
\nInjection Site Reactions: Transient pain, swelling, or warmth may occur immediately after injection.
\n5.Adverse Reactions
\nMost Common:
\nInjection site reactions are the primary adverse events, including:
\nPain (arthralgia)
\nSwelling (effusion)
\nErythema (redness)
\nWarmth at the injection site
\nThese symptoms are usually mild to moderate and resolve spontaneously within a few days to two weeks.
\n6.Drug Interactions
\nChemical Precipitation:
\nThis preparation may form a precipitate if mixed with disinfectants containing quaternary ammonium salts (e.g., Benzalkonium chloride) or Chlorhexidine.
\nAction: The injection site must be thoroughly flushed with sterile saline after disinfection if such agents are used.
\nConcurrent Therapy:
\nNot recommended to be mixed with other intra-articular injectable drugs.
\n7.Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: BDDE-Crosslinked Sodium Hyaluronate.
\nConcentration: Typically 20 mg\/mL (Total 60 mg\/3 mL).
\nAppearance: Clear, colorless to slightly yellow, viscous sterile liquid.
\nStorage: Store below 30\u00b0C. Do not freeze. Keep in the original package to protect from light.<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u6613\u5c3c\u5eb7 \u00ae(Hyruan ONE\u00ae)
\nGeneric Name: BDDE-Crosslinked Sodium Hyaluronate
\nStrength: 60 mg\/3 mL per pre-filled syringe
\nManufacturer: LG Chem, Ltd.
\nMarketing Authorization Holder: LG Chem, Ltd. (Domestic filing entity: Yifan Pharmaceutical Co., Ltd.)
\nApproval Date in China: April 7, 2023
\nRegistration Number: \u56fd\u836f\u51c6\u5b57HJ20233147
\nStorage: Store at 1\u201330\u00b0C, do not freeze. Keep the pre-filled syringe in the original package to protect from light. Refer to the package insert for detailed storage and handling instructions.<\/p>\n
Price&Cost:Contact Us now for the best price of BDDE-Crosslinked Sodium Hyaluronate \uff08Hyruan ONE\uff09<\/p>\n
<\/p>\n","protected":false},"featured_media":4058,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25],"product_tag":[],"class_list":["post-4057","product","type-product","status-publish","has-post-thumbnail","product_cat-injection","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n