1. Indications and Usage
\nSchizophrenia:
\nTreatment of schizophrenia in adults.
\nNote: This medication is indicated for patients who have been stabilized on oral aripiprazole or another antipsychotic medication.
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Intramuscular (IM) Injection ONLY.
\nAdministered by a healthcare professional into the deltoid or gluteal muscle.
\nRecommended Dosage:
\nDosing Options: Available in doses administered every 4 weeks, every 6 weeks, or every 8 weeks (e.g., 441 mg\/4 weeks, 662 mg\/4 weeks, 882 mg\/4 weeks, 1064 mg\/6 weeks, 1324 mg\/8 weeks).
\nCritical Administration Instructions (Loading Dose):
\nInitial Treatment: A loading dose injection (deltoid) is required immediately after the first injection to achieve therapeutic levels rapidly.
\nOral Supplementation: Oral aripiprazole supplementation (e.g., 10\u201320 mg\/day) is required for 14 days following the initiation of therapy to cover the gap until steady-state is reached.
\nMissed Dose: Protocol varies significantly based on the time elapsed since the last dose (ranging from 4 days to 8 weeks); strictly follow the prescribing guide for missed doses to prevent relapse.
\n3. Mechanism of Action
\nReceptor Profile:
\nAripiprazole is an atypical antipsychotic with high affinity for dopamine D2 and serotonin 5-HT1A receptors, and moderate affinity for 5-HT2A receptors.
\nPartial Agonist Activity:
\nActs as a partial agonist at D2 and 5-HT1A receptors.
\nActs as an antagonist at 5-HT2A receptors.
\nMicrosphere Technology:
\nThe drug is formulated in biodegradable polymer microspheres. Upon IM injection, the polymer slowly degrades, releasing arripiprazole gradually into the systemic circulation over weeks, maintaining stable plasma concentrations.
\n4. Safety and Warnings
\nIncreased Mortality in Elderly with Dementia (Boxed Warning):
\nElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
\nSuicidal Thoughts and Behaviors:
\nMonitor for the emergence of suicidal ideation and behavior.
\nInjection Site Reactions:
\nPain, erythema, and induration at the injection site may occur.
\nMetabolic Changes:
\nHyperglycemia, weight gain, and dyslipidemia may occur; monitor metabolic parameters regularly.
\nNeuroleptic Malignant Syndrome (NMS):
\nMonitor for NMS, a potentially fatal reaction.
\nTardive Dyskinesia:
\nRisk of developing abnormal involuntary movements.
\n5.Adverse Reactions
\nMost Common:
\nInjection site pain, headache, akathisia (inner restlessness), insomnia, and anxiety.
\n6.Drug Interactions
\nCYP3A4 and CYP2D6 Substrate:
\nAripiprazole is metabolized by CYP3A4 and CYP2D6 enzymes.
\nStrong CYP3A4 Inhibitors:
\nDose reduction is required (e.g., ketoconazole, itraconazole).
\nStrong CYP2D6 Inhibitors:
\nDose reduction is required (e.g., quinidine, fluoxetine).
\nCYP3A4 Inducers:
\nDose increase is required (e.g., carbamazepine, rifampin).
\n7.Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Aripiprazole.
\nExcipients: Poly(lactic-co-glycolic acid) (PLGA) \u2013 biodegradable polymer.
\nAppearance: Sterile, lyophilized (freeze-dried) powder in a vial; must be reconstituted with the provided solvent (NMP-based) prior to injection.
\nStorage: Store at 25\u00b0C (77\u00b0F); excursions permitted to 15\u201330\u00b0C (59\u201386\u00b0F).<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u963f\u4e3d\u552f \u00ae(Aliwei\u00ae)
\nGeneric Name: Aripiprazole Microspheres
\nStrength: 350 mg per vial (with 2 mL special solvent)
\nManufacturer: Zhuhai Livzon Microsphere Technology Co., Ltd.
\nMarketing Authorization Holder: Zhuhai Livzon Microsphere Technology Co., Ltd.
\nApproval Date in China: May 9, 2025
\nRegistration Number: \u56fd\u836f\u51c6\u5b57H20250011
\nStorage: Store at controlled room temperature (15\u201330\u00b0C\/59\u201386\u00b0F), protect from light and moisture. Reconstituted solution should be used immediately. Refer to the package insert for detailed storage and handling instructions.<\/p>\n
Price&Cost:Contact Us now for the best price of Aripiprazole Microspheres\uff08Aliwei\uff09<\/p>\n","protected":false},"featured_media":4070,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25,73],"product_tag":[],"class_list":["post-4069","product","type-product","status-publish","has-post-thumbnail","product_cat-injection","product_cat-chinese-innovative-drug","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n