1. Indications and Usage
\nMajor Depressive Disorder (MDD):
\nTreatment of major depressive disorder in adults.
\nObsessive-Compulsive Disorder (OCD):
\nTreatment of obsessive-compulsive disorder in adults.
\nPanic Disorder:
\nTreatment of panic disorder in adults.
\nSocial Anxiety Disorder:
\nTreatment of social anxiety disorder in adults.
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Oral Use ONLY.
\nRecommended Dosage:
\nStarting Dose: Typically 25 mg once daily.
\nTitration: Dose can be increased in increments (e.g., 12.5 mg\/day) at intervals of at least 1 week based on clinical response and tolerability.
\nMaintenance: Recommended dose range is 25 mg to 62.5 mg once daily.
\nMaximum Dose: Typically 62.5 mg once daily.
\nCritical Administration Instructions:
\nTake with Food: Should be taken during or after a meal (breakfast is recommended) to minimize gastrointestinal side effects.
\nSwallow Whole: Tablets must be swallowed whole. Do not chew, crush, or split the tablets, as this will destroy the enteric-coated sustained-release structure.
\n3. Mechanism of Action
\nSSRI Activity:
\nParoxetine is a potent and selective inhibitor of the neuronal reuptake of serotonin (5-hydroxytryptamine, 5-HT).
\nNeurotransmitter Modulation:
\nBy blocking the serotonin transporter (SERT), it increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission.
\nSelectivity:
\nIt has minimal effect on neuronal norepinephrine or dopamine reuptake at therapeutic doses.
\n4. Safety and Warnings
\nSuicidal Thoughts and Behaviors (Boxed Warning):
\nAntidepressants increase the risk of suicidal thinking and behavior in children, adolescents, and young adults.
\nSerotonin Syndrome:
\nPotentially life-threatening condition that can occur with serotonergic drugs.
\nBleeding Risk:
\nSSRIs may increase the risk of bleeding events (e.g., ecchymosis, purpura, GI bleeding).
\nDiscontinuation Syndrome:
\nParoxetine has a high incidence of withdrawal symptoms (e.g., dizziness, paresthesia, anxiety, nausea) upon abrupt cessation. Gradual tapering is mandatory.
\nSexual Dysfunction:
\nMay cause decreased libido, delay or inhibition of orgasm, or erectile dysfunction.
\nWeight Gain:
\nLong-term use may be associated with weight gain.
\n5.Adverse Reactions
\nMost Common:
\nNausea, somnolence, insomnia, dry mouth, decreased appetite, constipation, and sexual dysfunction.
\n6.Drug Interactions
\nMAO Inhibitors (Contraindicated):
\nContraindicated within 14 days of discontinuing an MAOI.
\nCYP2D6 Inhibitor:
\nParoxetine is a potent inhibitor of CYP2D6. It may increase the plasma levels of drugs metabolized by this enzyme (e.g., Type 1C antiarrhythmics, risperidone, atomoxetine).
\nThioridazine (Contraindicated):
\nContraindicated due to the risk of serious, potentially fatal, cardiac arrhythmias.
\n7.Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Paroxetine Hydrochloride.
\nAvailable Strength: 12.5 mg, 25 mg tablets.
\nAppearance: Film-coated tablets (colors vary by strength).
\nStorage: Store at controlled room temperature (20\u00b0C to 25\u00b0C).<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name:\u8d5b\u4e50\u7279 \u00ae(Seroxat CR\u00ae)
\nGeneric Name: Paroxetine Hydrochloride
\nStrength: 25 mg paroxetine per tablet, 10 tablets per box
\nManufacturer: BORA PHARMACEUTICAL SERVICES INC.
\nMarketing Authorization Holder: GlaxoSmithKline Inc.
\nDomestic Agent: GlaxoSmithKline (China) Investment Co., Ltd.
\nApproval Date in China: January 2017
\nRegistration Number: \u56fd\u836f\u51c6\u5b57HJ20170001
\nStorage: Store at controlled room temperature (15\u201330\u00b0C), keep tightly sealed and protected from light and moisture. Refer to the package insert for detailed storage instructions.<\/p>\n
Price&Cost:Contact Us now for the best price of Paroxetine Hydrochloride\uff08Seroxat CR\uff09<\/p>\n","protected":false},"featured_media":4080,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[27],"product_tag":[],"class_list":["post-4079","product","type-product","status-publish","has-post-thumbnail","product_cat-tablets","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n