1. Indications and Usage
\nNeovascular (Wet) Age-Related Macular Degeneration (nAMD):
\nTreatment of patients with nAMD.
\nDiabetic Macular Edema (DME):
\nTreatment of patients with DME.
\nRetinal Vein Occlusion (RVO):
\nTreatment of macular edema following central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO).
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Intravitreal Injection ONLY. Must be administered by an ophthalmologist.
\nRecommended Dosage:
\nDose: 6 mg (0.05 mL) per injection.
\nSchedule:
\nInitial Phase: Once every 4 weeks (monthly) for the first 3 months.
\nMaintenance Phase: Once every 8\u201316 weeks thereafter, based on disease activity.
\nDosing Interval: The dosing interval may be extended up to 16 weeks using a Treat-and-Extend (T&E) regimen.
\nCritical Administration Instructions:
\nSterile Technique: Administer under sterile conditions with appropriate anesthesia and topical broad-spectrum bacteriostatic agent.
\nInjection Site: Typically injected into the vitreous cavity (e.g., 3\u20134 mm posterior to the limbus).
\n3. Mechanism of Action
\nDual-Antagonist Activity:
\nFaricimab is a bispecific IgG1 antibody that binds with high affinity to both VEGF-A and Angiopoietin-2 (Ang-2).
\nPathway Inhibition:
\nAnti-VEGF-A: Inhibits pathological angiogenesis and reduces vascular permeability (edema), similar to existing anti-VEGF therapies.
\nAnti-Ang-2: Stabilizes blood vessels. Ang-2 destabilizes vessels and primes them for leakage; inhibiting it strengthens vessel integrity and reduces inflammation.
\nTherapeutic Result: Dual pathway inhibition provides enhanced and potentially more durable disease control compared to single-pathway inhibition.
\n4. Safety and Warnings
\nEndophthalmitis and Retinal Detachment:
\nIntravitreal injections carry a risk of intraocular infection and retinal detachment.
\nIntraocular Pressure (IOP) Spikes:
\nIOP may increase transiently immediately following injection.
\nThromboembolic Events:
\nNon-fatal stroke, myocardial infarction, or vascular death may occur.
\nContraindications:
\nActive or suspected ocular or periocular infections.
\nSevere active intraocular inflammation.
\nHypersensitivity to the drug.
\n5.Adverse Reactions
\nMost Common:
\nConjunctival hemorrhage, eye pain, vitreous floaters, cataract, and increased intraocular pressure.
\nNote: The safety profile is generally comparable to that of aflibercept.
\n6.Drug Interactions
\nNo Clinical Significance:
\nNo specific drug-drug interaction studies have been conducted. Concomitant use with other anti-VEGF agents is generally avoided.
\n7.Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Faricimab.
\nAppearance: Clear, colorless to slightly yellowish solution.
\nPackaging: Single-dose vial (6 mg\/0.05 mL).
\nStorage: Store in a refrigerator at 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F). Do not freeze or shake.<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name: \u7f57\u89c6\u4f73 \u00ae(Vabysmo\u00ae )
\nGeneric Name: Faricimab
\nStrength: 6 mg (0.05 mL) per vial, 1 vial per box
\nManufacturer: Roche Diagnostics GmbH \/ Genentech, Inc.
\nMarketing Authorization Holder: F. Hoffmann-La Roche Ltd
\nDomestic Responsible Entity: Shanghai Roche Pharmaceuticals Co., Ltd.
\nApproval Date in China: December 13, 2023
\nRegistration Number:\u56fd\u836f\u51c6\u5b57 SJ20230018
\nStorage: Store refrigerated at 2\u00b0C\u20138\u00b0C, do not freeze or shake. Keep in original carton to avoid light exposure. Unopened vials can be stored at 20\u00b0C\u201325\u00b0C for up to 24 hours before administration, use immediately after preparation. Refer to the package insert for complete storage rules.<\/p>\n
Price&Cost:Contact Us now for the best price of Faricimab\uff08Vabysmo\uff09<\/p>\n","protected":false},"featured_media":4185,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[79],"product_cat":[25],"product_tag":[],"class_list":["post-4184","product","type-product","status-publish","has-post-thumbnail","product_brand-roche","product_cat-injection","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n