1. Indications and Usage
\nReversal of Neuromuscular Blockade (NMB):
\nReversal of rocuronium bromide or vecuronium bromide neuromuscular blockade in adult and pediatric patients (2 years of age and older).
\nNote: It is indicated for the reversal of moderate to deep blockade.
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Intravenous (IV) Injection ONLY.
\nRecommended Dosage (Adults):
\nReversal of Moderate Blockade:
\nDose: 2 mg\/kg.
\nTiming: When 1\u20132 twitches are present in a Train-of-Four (TOF) monitoring.
\nReversal of Deep Blockade:
\nDose: 4 mg\/kg.
\nTiming: When 1\u20132 Post-Tetanic Count (PTC) stimuli are present.
\nImmediate Reversal (Emergency):
\nDose: 16 mg\/kg.
\nTiming: Immediately after administration of rocuronium (e.g., “Cannot Intubate, Cannot Ventilate” scenario).
\nCritical Administration Instructions:
\nAdminister as a single IV bolus injection over 10 seconds or less.
\nMust be administered by anesthesia professionals familiar with neuromuscular monitoring.
\n3. Mechanism of Action
\nSelective Binding Agent:
\nSugammadex is a chemically modified \u03b3-cyclodextrin with a lipophilic core and a hydrophilic exterior.
\nEncapsulation (Host-Guest Chemistry):
\nIt selectively binds to rocuronium and vecuronium (steroidal NMBAs) in a 1:1 stoichiometric ratio, forming a tight, non-covalent inclusion complex.
\nTherapeutic Result: By sequestering the free NMBA molecules in the plasma, it creates a concentration gradient that pulls the NMBA away from the neuromuscular junction, rapidly reversing the blockade.
\nSpecificity: It does not bind to benzylisoquinolinium NMBAs (e.g., cisatracurium, mivacurium) or succinylcholine.
\n4. Safety and Warnings
\nHypersensitivity Reactions:
\nSerious hypersensitivity reactions (e.g., anaphylaxis, angioedema, rash) have been reported.
\nReappearance of Blockade:
\nReappearance of neuromuscular blockade may occur after initial reversal. Patients must be monitored for at least 24 hours (or until stable) to ensure adequate recovery of muscle function.
\nRenal Impairment:
\nSugammadex is primarily excreted unchanged by the kidneys.
\nContraindication: Not recommended for patients with severe renal impairment (CrCl < 30 mL\/min) or those requiring dialysis, as the complex may accumulate and cause prolonged paralysis.
\nBleeding Risk:
\nCaution is advised in patients with coagulation disorders or those undergoing procedures with high bleeding risk.
\n5.Adverse Reactions
\nMost Common:
\nHeadache, nausea, vomiting, hypotension, hypertension, coughing, and incomplete reversal.
\n6.Drug Interactions
\nHormonal Contraceptives:
\nSugammadex binds to progesterone. It may reduce the efficacy of hormonal contraceptives.
\nAction: Patients should use an alternative non-hormonal contraceptive method for 7 days after receiving Sugammadex.
\nOther Drugs:
\nInteraction with drugs that are highly protein-bound is theoretically possible but clinically rare.
\n7.Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Sugammadex Sodium.
\nAppearance: Clear, colorless to slightly yellow solution.
\nExcipients: Hydrochloric acid, sodium hydroxide, Water for Injection.
\nStorage: Store at 25\u00b0C (77\u00b0F); excursions permitted to 15\u201330\u00b0C (59\u201386\u00b0F).<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name:\u79d1\u8212\u4ead \u00ae(Keshuting\u00ae)
\nGeneric Name: Sugammadex Sodium
\nStrength: 200 mg per 2 mL vial
\nManufacturer: Hunan Kelun Pharmaceutical Co., Ltd.
\nMarketing Authorization Holder: Hunan Kelun Pharmaceutical Co., Ltd.
\nApproval Date in China: 2022
\nRegistration Number: \u56fd\u836f\u51c6\u5b57H20223277
\nStorage: Store at 10\u201330\u00b0C, protected from light; do not freeze. Refer to the package insert for full storage specifications.<\/p>\n
Price&Cost:Contact Us now for the best price of Sugammadex Sodium\uff08Keshuting\uff09<\/p>\n","protected":false},"featured_media":4187,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25,73],"product_tag":[],"class_list":["post-4186","product","type-product","status-publish","has-post-thumbnail","product_cat-injection","product_cat-chinese-innovative-drug","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n