1. Indications and Usage
\nAcute Decompensated Heart Failure:
\nIntravenous treatment of patients with acute decompensated heart failure who have dyspnea at rest or with minimal exertion (NYHA Class > II) .
\n2. Dosage and Administration
\nRoute of Administration:
\nFor Intravenous (IV) Injection and Infusion ONLY.
\nRecommended Dosage:
\nLoading Dose: Administer 1.5 \u00b5g\/kg intravenously over approximately 60 seconds.
\nMaintenance Infusion: Immediately follow with a continuous infusion at a rate of 0.0075 \u00b5g\/kg\/min .
\nDuration: Typically administered continuously for 24 to 72 hours, depending on clinical response .
\nCritical Administration Instructions:
\nReconstitution: Dissolve with Sterile Water for Injection. Do not shake vigorously; gently swirl to avoid foaming .
\nCompatibility: Do not mix with heparin, insulin, furosemide, or drugs containing sodium metabisulfite in the same line. Do not use heparin-bonded catheters .
\n3. Mechanism of Action
\nVasodilation:
\nBinds to natriuretic peptide receptors on vascular smooth muscle cells, increasing intracellular cGMP, which leads to the relaxation of both arterial and venous smooth muscles .
\nHemodynamic Effects:
\nReduces systemic vascular resistance (afterload) and pulmonary capillary wedge pressure (preload), thereby improving cardiac output .
\nRenal Effects:
\nActs as a natural antagonist to the Renin-Angiotensin-Aldosterone System (RAAS), promoting natriuresis (sodium excretion) and diuresis without increasing myocardial oxygen consumption .
\n4. Safety and Warnings
\nHypotension:
\nThe most common adverse reaction is a significant drop in blood pressure.
\nContraindication: Contraindicated in patients with cardiogenic shock or systolic blood pressure <90 mmHg .
\nRenal Function Impairment:
\nMay cause transient elevation of serum creatinine. Monitor renal function periodically .
\nCautions:
\nUse with caution in patients with severe valvular stenosis, restrictive cardiomyopathy, or cardiac tamponade .
\n5.Adverse Reactions and Clinical Research
\nMost Common Adverse Reactions:
\nHypotension, headache, nausea, vomiting, sweating, and transient increase in serum creatinine .
\nClinical Research Highlights:
\nClinical trials demonstrated that the drug rapidly improves dyspnea and hemodynamic parameters compared to standard therapy.
\nSymptomatic hypotension was the primary reason for dose reduction or discontinuation .
\n6.Drug Interactions
\nACE Inhibitors:
\nConcomitant use with oral ACE inhibitors may increase the risk of symptomatic hypotension .
\nIncompatible Drugs:
\nPhysically incompatible with heparin, insulin, bumetanide, enalaprilat, ethacrylate sodium, hydralazine, and furosemide when administered via the same IV catheter .
\n7.Pharmaceutical Information
\nChemical Composition:
\nActive Ingredient: Recombinant Human Brain Natriuretic Peptide.
\nAppearance: White to off-white lyophilized powder.
\nPackaging: Single-use vial (0.5 mg \/ 500 Units).
\nStorage: Store at 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F). Protect from light .<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name:\u65b0\u6d3b\u7d20 \u00ae(Xinhuosu\u00ae)
\nGeneric Name: Recombinant Human Brain Natriuretic Peptide
\nStrength: 0.5 mg (500 U) per vial, 1 vial per box
\nManufacturer: Chengdu Tiantaishan Pharmaceutical Co., Ltd.
\nMarketing Authorization Holder: Chengdu Tiantaishan Pharmaceutical Co., Ltd.
\nApproval Date in China: 2005
\nRegistration Number: \u56fd\u836f\u51c6\u5b57S20050033
\nStorage: Store and transport at 2\u00b0C\u20138\u00b0C, protected from light; do not freeze. Refer to the full package insert for detailed storage instructions.<\/p>\n
Price&Cost:Contact Us now for the best price of Recombinant Human Brain Natriuretic Peptide\uff08Xinhuosu\uff09<\/p>\n","protected":false},"featured_media":4374,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25,73],"product_tag":[],"class_list":["post-4373","product","type-product","status-publish","has-post-thumbnail","product_cat-injection","product_cat-chinese-innovative-drug","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n