1. Indications and Usage
\nTreatment of serious, life-threatening fungal infections caused by susceptible strains of Aspergillus, Candida, Cryptococcus, and others. Specific indications include:
\nSystemic Fungal Infections: Aspergillosis, blastomycosis, coccidioidomycosis, and cryptococcosis.
\nLeishmaniasis: Treatment of visceral leishmaniasis (kala-azar).
\nFever in Neutropenic Patients: Empiric treatment of fever in neutropenic patients suspected to have fungal infections.
\n2. Dosage and Administration
\nRoute of Administration: For Intravenous (IV) Infusion ONLY. Intrathecal administration is contraindicated.
\nRecommended Dosage:
\nFungal Infections: Typically 0.5 to 1.0 mg\/kg\/day, titrated up to 1.5 mg\/kg\/day based on clinical response and tolerance.
\nLeishmaniasis: 1.0 to 1.5 mg\/kg\/day for 10 days.
\nCritical Administration Instructions:
\nDilution: Reconstitute and dilute ONLY in 5% Glucose Injection. Do not use 0.9% Sodium Chloride.
\nInfusion Time: Infuse over 60 to 120 minutes.
\nFiltration: Use a 5-micron or polyvinyl alcohol inline filter during administration.
\nPre-medication: Administer acetaminophen, diphenhydramine, or hydrocortisone prior to infusion to minimize infusion-related reactions.
\n3. Mechanism of Action
\nMembrane Disruption: Amphotericin B binds to ergosterol, a key component of fungal cell membranes.
\nPore Formation: This binding creates transmembrane pores, leading to leakage of intracellular potassium, magnesium, and other essential molecules, ultimately causing fungal cell death.
\nComplex Advantage: In this cholesterol sulfate complex formulation, the drug is encapsulated within a lipid bilayer, which reduces its binding to mammalian cell cholesterol, thereby lowering toxicity.
\n4. Safety and Warnings
\nNephrotoxicity: Dose-dependent renal impairment remains the primary concern. Monitor serum creatinine and BUN regularly; hydration with 0.9% Sodium Chloride before infusion is recommended.
\nInfusion-Related Reactions: Fever, chills, rigors, and nausea are common, especially during the first few infusions.
\nElectrolyte Abnormalities: Significant hypokalemia and hypomagnesemia frequently occur and require routine monitoring and supplementation.
\nHypersensitivity: Anaphylactic reactions can occur; emergency resuscitation equipment must be available.
\n5. Adverse Reactions and Clinical Research
\nMost Common Adverse Reactions: Nephrotoxicity, hypokalemia, hypomagnesemia, anemia, infusion-related reactions, nausea, and vomiting.
\nClinical Research Highlights: Clinical data demonstrate that this lipid complex formulation achieves comparable antifungal efficacy to conventional amphotericin B but with a significantly lower incidence of severe nephrotoxicity and infusion-related toxicity.
\n6. Drug Interactions
\nNephrotoxic Agents: Concomitant use with aminoglycosides, cyclosporine, or other nephrotoxic drugs increases the risk of renal failure.
\nCardiac Glycosides: Hypokalemia induced by amphotericin B increases the risk of digitalis toxicity.
\nAntineoplastic Agents: May exacerbate bone marrow suppression when used with cytotoxic chemotherapy.
\n7. Pharmaceutical Information
\nChemical Composition: Amphotericin B formulated as a complex with cholesterol sulfate.
\nAppearance: Yellow to orange lyophilized cake or loose body.
\nPackaging: Single-use vial (50 mg).
\nStorage: Store in the original carton at 2\u00b0C to 8\u00b0C. Do not freeze.<\/p>\n","protected":false},"excerpt":{"rendered":"
Brand Name:\u5b89\u590d\u5229\u514b \u00ae\uff08Anfulike\u00ae\uff09
\nGeneric Name: Amphotericin B Cholesteryl Sulfate Complex
\nStrength: 50 mg per vial
\nManufacturer: CSPC Ouyi Pharmaceutical Co., Ltd.
\nMarketing Authorization Holder: CSPC Ouyi Pharmaceutical Co., Ltd.
\nApproval Date in China: March 31, 2021
\nRegistration Number: \u56fd\u836f\u51c6\u5b57H20213238
\nStorage: Store at room temperature, sealed and protected from light. Avoid freezing and high temperature. Refer to the full package insert for storage after reconstitution.<\/p>\n
Price&Cost:Contact Us now for the best price of Amphotericin B Cholesteryl Sulfate Complex\uff08Anfulike\uff09<\/p>\n","protected":false},"featured_media":4458,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25,73],"product_tag":[],"class_list":["post-4457","product","type-product","status-publish","has-post-thumbnail","product_cat-injection","product_cat-chinese-innovative-drug","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\n