Deanxit Flupentixol and Melitracen Tablets

1. Indications and Usage
Depression and Anxiety: Treatment of mild and moderate depression and anxiety, including neurasthenia, psychogenic depression, and somatic symptom disorders with emotional indifference.
2. Dosage and Administration
Adults: The usual dose is 2 tablets daily, taken as 1 in the morning and 1 at noon. For severe cases, 2 tablets may be taken in the morning. The maximum daily dose is 4 tablets.
Elderly: Typically 1 tablet in the morning.
Maintenance: Usually 1 tablet daily in the morning. For insomnia or severe restlessness, mild sedatives may be added during the acute phase.
3. Mechanism of Action
Flupentixol: A thioxanthene antipsychotic that acts primarily as a dopamine D2 receptor antagonist, providing mild antipsychotic and activating effects.
Melitracen: A tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine, alleviating depressive and anxious symptoms.
4. Safety and Warnings
Suicidal Ideation: Antidepressants increase the risk of suicidal thinking and behavior in children and adolescents.
Cardiovascular Risks: Not recommended for patients with recent myocardial infarction, heart block, or coronary ischemia.
Contraindications: Contraindicated in unrepaired narrow-angle glaucoma, urinary retention, severe hepatic impairment, and patients taking monoamine oxidase inhibitors (MAOIs).
CNS Depression: May cause drowsiness and impair driving or machinery operation.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Insomnia, anxiety, restlessness, tremor, extrapyramidal symptoms, dry mouth, constipation, and tachycardia.
Clinical Research: Clinical studies demonstrate efficacy in reducing depressive and anxiety symptoms with a favorable short-term tolerability profile.
6. Drug Interactions
MAOIs: Concomitant use is contraindicated due to the risk of serotonin syndrome and hypertensive crisis.
CNS Depressants: Potentiates the effects of alcohol, barbiturates, and other central nervous system depressants.
Antihypertensives: May reduce the effectiveness of drugs like guanethidine and clonidine.
QT-Prolonging Drugs: Co-administration with drugs known to prolong the QT interval increases the risk of arrhythmias.
7. Pharmaceutical Information
Active Ingredients: Flupentixol 0.5 mg and Melitracen 10 mg per tablet.
Appearance: Film-coated tablets (white or off-white after peeling).
Storage: Store at controlled room temperature, protected from moisture.