Ganxin Metadoxine Tablets

1. Indications and Usage
Liver Disorders: Adjunctive treatment for hepatitis and fatty liver.
Alcoholic Liver Disease: Used to facilitate the metabolism of ethanol and alleviate symptoms associated with alcoholic liver damage.
2. Dosage and Administration
Adults: The usual dosage is 1 to 2 tablets per dose, taken 3 times daily.
Administration: Tablets should be swallowed with water after meals.
Duration: The course of treatment is typically determined by the severity of the liver condition and the clinical response.
3. Mechanism of Action
Ethanol Metabolism: It accelerates the metabolism of ethanol, reduces the toxicity of alcohol, and helps restore liver function.
Membrane Protection: The drug protects hepatocyte membranes, promotes liver cell regeneration, and improves lipid metabolism.
Antispasmodic Effect: It possesses antispasmodic properties that help alleviate abdominal discomfort associated with liver diseases.
4. Safety and Warnings
Contraindications: Contraindicated in patients with known hypersensitivity to the drug or its components.
Special Populations: Use with caution in patients with severe renal or hepatic impairment. Safety in children and pregnant women has not been fully established.
Precautions: Patients should be monitored for liver function improvement during treatment.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Occasionally, gastrointestinal discomfort, nausea, or abdominal pain may occur.
Allergic Reactions: Rare instances of allergic skin reactions, such as rash or pruritus, have been reported.
6. Drug Interactions
Interaction Profile: Specific drug interaction data is not fully established. Concomitant use with other medications may cause interactions; consultation with a physician or pharmacist is advised.
7. Pharmaceutical Information
Active Ingredient: Metadoxine (a complex of pyrrolidonecarboxylic acid and L-threonine).
Strength: Typically 250 mg or 500 mg per tablet.
Appearance: Sugar-coated tablets or film-coated tablets, usually white or off-white.
Storage: Keep in a light-resistant, tightly closed container in a dry place.