Getai Diosmin Tablets

1. Indications and Usage
Venous and Lymphatic Insufficiency: Indicated for the treatment of symptoms associated with chronic venous-lymphatic insufficiency (e.g., heavy legs, pain, morning leg swelling, and varicose veins).
Hemorrhoids: Indicated for the treatment of symptoms associated with acute hemorrhoidal attacks.
2. Dosage and Administration
Venous Insufficiency: The usual dosage is one 0.5g tablet twice daily (at lunch and dinner).
Acute Hemorrhoids: The dosage is higher for the first 4 days (3 tablets twice daily), followed by 2 tablets twice daily for the next 3 days.
Administration: Should be taken orally with meals.
3. Mechanism of Action
Venous Tone: Diosmin increases venous tone and decreases venous distensibility and venous stasis.
Microcirculation: It normalizes capillary permeability and increases capillary resistance, improving microcirculation.
4. Safety and Warnings
Hemorrhoid Precautions: Treatment of acute hemorrhoids must be short-term. If symptoms do not resolve quickly, a proctological examination is necessary.
Contraindications: Contraindicated in patients with hypersensitivity to the active substance or any excipients.
Special Populations: Animal studies have not shown teratogenic effects. However, data in pregnant and breastfeeding women is lacking; breastfeeding is not recommended during treatment.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: There have been reports of minor gastrointestinal discomfort and autonomic nervous system disturbances. These are generally mild and do not typically require discontinuation of therapy.
Clinical Research: Double-blind, placebo-controlled trials have confirmed its efficacy in treating chronic lower limb venous insufficiency (both functional and organic).
6. Drug Interactions
Interaction Profile: No significant drug interactions with other medications have been identified to date.
Elderly Patients: In patients over 70 years old, the incidence of adverse reactions is not significantly different, and no interactions with drugs used for hypertension, atherosclerosis, diabetes, or neuropsychiatric conditions have been observed.
7. Pharmaceutical Information
Active Ingredient: Diosmin.