Livzon Changle Bifidobacterium Live Capsules

Brand Name: 丽珠肠乐®(Livzon Changle®)
Generic Name: Bifidobacterium Live
Strength: 0.35 g per capsule
Manufacturer: Livzon Pharmaceutical Group Inc.
Marketing Authorization Holder: Livzon Pharmaceutical Group Inc.
Approval Date in China: 2002‑06‑14
Registration Number: National Drug Approval No. S10960040
Storage: Store sealed at 2‑8℃, protected from light

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1. Indications and Usage
Intestinal Flora Imbalance: Indicated for the treatment of acute and chronic diarrhea, constipation, and dyspepsia caused by intestinal flora disorders.
Adjunctive Therapy: Used to restore the normal microecological environment in the gastrointestinal tract and inhibit the growth of potentially harmful pathogenic bacteria.
2. Dosage and Administration
Adults: The usual dosage is 1 to 2 capsules per dose, taken twice daily (morning and evening).
Administration: Capsules should be taken orally after meals with cool or warm water. Do not use hot water.
Pediatric Use: For infants or children unable to swallow capsules, the capsule may be opened and the powder mixed with warm water or warm milk for oral administration.
3. Mechanism of Action
Biological Barrier: Bifidobacterium colonizes the surface of the intestinal mucosa, forming a biological barrier that prevents the adhesion and invasion of pathogenic bacteria.
pH Regulation: The bacteria produce lactic acid and acetic acid, which lower the intestinal pH and inhibit the growth of harmful bacteria.
Metabolic Support: It promotes the digestion and absorption of nutrients, synthesizes essential vitamins, and stimulates host immunity.
4. Safety and Warnings
Temperature Control: As a live bacterial preparation, it must not be exposed to high temperatures. It should be taken with water below 40°C.
Storage: Must be stored in a refrigerator at 2°C to 8°C, protected from light.
Hypersensitivity: Contraindicated in patients with known hypersensitivity to bifidobacteria or any excipients.
Special Populations: Pregnant and breastfeeding women should use this medication under the guidance of a physician.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Generally well-tolerated. No significant adverse reactions have been observed at recommended doses.
Management: If any unexpected symptoms occur, discontinue use and consult a healthcare professional.
6. Drug Interactions
Antibiotics: Concurrent use with antibacterial drugs may weaken the efficacy of this product. They should be taken separately with a significant time interval.
Antacids and Adsorbents: Antacids, bismuth preparations, tannic acid, and activated charcoal can inhibit, adsorb, or kill the live bacteria. These should not be taken concurrently.
7. Pharmaceutical Information
Active Ingredient: Bifidobacterium (live bacteria).
Strength: Typically 0.35 g per capsule (containing not less than 50 million viable bacteria).
Appearance: Hard gelatin capsules containing greyish-white or greyish-yellow powder with uniform particles.
Storage: Store and transport at 2°C to 8°C, protected from light.

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