- Indications and Usage Bowel Preparation: Indicated for bowel preparation prior to colonoscopy in adult patients.
- Dosage and Administration Standard Dosing: The usual regimen involves taking two bottles. Each bottle’s contents must be diluted with water to approximately 0.5 liters, after which the patient must drink an additional 1 liter of clear liquids within two hours. Administration: Typically administered in divided doses (e.g., the evening before and the morning of the examination) according to clinical requirements. It is essential to follow dietary restrictions on clear liquids prior to the procedure.
- Mechanism of Action Osmotic Laxative Effect: This concentrated oral solution works via an osmotic mechanism. The high concentration of sulfate, sodium, potassium, and magnesium ions increases the osmotic pressure within the intestinal lumen, preventing water absorption and thereby promoting the evacuation of intestinal contents.
- Safety and Warnings Cardiac and Renal Risk: Hypersensitivity and cardiovascular adverse events (such as cardiac arrest) may occur, particularly in patients with severe cardiovascular or renal impairment. Intestinal Perforation: Rare cases of intestinal perforation have been reported, mainly in patients with pre-existing inflammatory bowel disease or bowel obstruction. Renal Impairment: Caution is required for patients with severe renal impairment. The medication should generally not be used in this population without careful evaluation due to the risk of electrolyte abnormalities.
- Adverse Reactions and Clinical Research Common Adverse Reactions: Abdominal discomfort, nausea, vomiting, bloating, and diarrhea are very common during bowel preparation. Serious Adverse Reactions: Electrolyte imbalances (including hypermagnesemia, hyperkalemia, or hypernatremia) and dehydration may occur, especially in vulnerable populations.
- Drug Interactions Nephrotoxic Medications: Concomitant use with other nephrotoxic drugs may increase the risk of renal impairment. Cardiac Medications: High doses of magnesium or potassium can affect cardiac conduction. Caution is advised when used with medications that affect potassium levels (e.g., ACE inhibitors, potassium-sparing diuretics).
- Pharmaceutical Information Active Ingredients: Magnesium Sulfate, Sodium Sulfate, and Potassium Sulfate. Exipients: Includes citric acid, L-malic acid, sodium benzoate, sucralose, and raspberry flavor. Storage: Store at controlled room temperature, protecting from freezing.
Yisijing Magnesium Sulfate Sodium Sulfate and Potassium Sulfate Concentrate Oral Solution
Brand Name: 益思净 ®（Yisijing®）
Generic Name: Magnesium Sulfate Sodium Sulfate and Potassium Sulfate
Strength: Each bottle is 176 mL, containing magnesium sulfate heptahydrate 3.276 g, anhydrous sodium sulfate 17.510 g and potassium sulfate 3.130 g; 2 bottles per box
Manufacturer: BEAUFOUR IPSEN INDUSTRIE
Marketing Authorization Holder: Ipsen Pharma SAS
Approval Date in China: November 30, 2022
Registration Number: 国药准字HJ20220094
Storage: Store in original packaging below 30°C and protect from light; no special low-temperature requirements. Refer to the full package insert for detailed storage specifications.
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