How much does AUGTYRO (Repotrectinib Capsules) Cost& price without insurance in China?
AUGTYRO® is the commercial brand name of Repotrectinib Capsules, a next-generation, orally active, highly selective dual inhibitor of tropomyosin receptor kinase (TRK) and rearranged during transfection (RET) developed by Bristol Myers Squibb. It exerts anti-tumor activity by potently inhibiting the kinase activity of TRK and RET, including overcoming acquired resistance mutations, thereby blocking downstream signaling pathways and suppressing the proliferation and survival of tumor cells harboring NTRK or RET gene fusions.
Main Indications
Treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangements;
Treatment of adult patients with solid tumors harboring NTRK gene fusions, who have progressed following prior treatment with other TRK inhibitors.
Common Side Effects
Common adverse reactions: Dizziness, dysgeusia, peripheral neuropathy, fatigue, constipation, dyspnea, nausea, anemia, myalgia, and cognitive impairment.
Laboratory abnormalities: Decreased neutrophil count, decreased lymphocyte count, decreased hemoglobin, increased transaminases, and increased creatinine.
Severe but manageable risks: Central nervous system adverse reactions (including dizziness, cognitive impairment, and mood disorders), interstitial lung disease/pneumonitis, and hepatotoxicity.
Approval Status in China
AUGTYRO® (Repotrectinib Capsules, 40mg) was conditionally approved for marketing in China in November 2023. It is currently a prescription drug and pending inclusion in China’s national medical insurance.
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