Synlian® is the commercial brand name of Linaprazan Glurate, a novel potassium-competitive acid blocker independently developed in China. It inhibits gastric acid secretion by reversibly blocking the potassium binding site of H+/K+-ATPase in gastric parietal cells, providing long-lasting acid suppression.
Main Indications
For the treatment of reflux esophagitis in adult patients.
Clinical Research
Phase III clinical trials confirmed that linaprazan glurate achieved high healing rates of reflux esophagitis, and showed rapid and sustained gastric acid suppression. The safety profile was well tolerated, supporting its new drug application and marketing approval in China.
Common Side Effects
Common adverse reactions include diarrhea, abdominal distension, nausea, elevated transaminase, hypertriglyceridemia, headache and dizziness.
Approval Status in China
Synlian® (Linaprazan Glurate Capsules) was officially approved for marketing in China in 2024, with the specification of 50mg. It is a domestically innovative prescription drug for acid-related gastrointestinal diseases.
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