Epidaza® is the commercial brand name of Chidamide, a novel orally active histone deacetylase inhibitor independently developed in China. It can selectively inhibit histone deacetylase, induce tumor cell apoptosis and cell cycle arrest, and exert anti-tumor effects.
Main Indications
For the treatment of relapsed or refractory peripheral T-cell lymphoma in adult patients who have received at least one prior systemic chemotherapy.
Clinical Research
A pivotal phase II clinical study demonstrated that chidamide achieved a confirmed objective response rate in patients with relapsed/refractory peripheral T-cell lymphoma. The study supported the new drug application and approval of chidamide in China, with a controllable safety profile.
Common Side Effects
Hematological adverse reactions: Neutropenia, thrombocytopenia, anemia, lymphopenia;
Non-hematological adverse reactions: Fatigue, fever, gastrointestinal discomfort, hypokalemia, hypoalbuminemia.
Approval Status in China
Epidaza® (Chidamide Tablets) was officially approved for marketing in China in 2014, with the specification of 5mg. It is a domestically innovative prescription anti-tumor drug.
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