How much does Noxafil (Posaconazole Enteric-coated Tablets) Cost& price without insurance in China?
Noxafil® is the commercial brand name of Posaconazole Enteric-coated Tablets, an orally active triazole antifungal developed by MSD. It inhibits fungal lanosterol synthesis by blocking cytochrome P450-dependent 14α-demethylase, resulting in fungal cell membrane damage and bacteriostatic/fungicidal effects.
Main Indications
Prophylaxis of invasive fungal infections in immunocompromised patients such as hematological malignancy or hematopoietic stem cell transplant recipients;
Treatment of invasive aspergillosis, fusariosis and other refractory invasive fungal infections.
Common Side Effects
Common mild adverse reactions: Nausea, diarrhea, vomiting, abdominal discomfort and headache.
Laboratory abnormalities: Transient elevation of hepatic transaminases.
Severe but manageable risks: Severe liver injury, arrhythmia related to QT prolongation and severe hypersensitivity.
Approval Status in China
Noxafil® (Posaconazole Enteric-coated Tablets, 100mg, domestic Chinese brand name: Nuokefei) was officially approved for marketing in China in 2014. It is currently a prescription drug included in China’s Category B medical insurance.
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