TUL：UBT251 has initiated a Phase III clinical trial.
On June 15, the Drug Clinical Trial Registration and Information Disclosure Platform showed that The United Laboratories (TUL) has registered a Phase III clinical trial (overweight/obesity) for UBT251 Injection.
This is a randomized, double-blind, parallel, placebo-controlled Phase III study designed to evaluate the efficacy and safety of UBT251 Injection in overweight/obese participants. The primary endpoints are the percentage change in body weight from baseline at Week 52 and the proportion of participants achieving a ≥5% reduction in body weight from baseline.
UBT251 is a long-acting GLP-1/GIP/GCG triple receptor agonist. To date, it has been approved to conduct clinical trials in China and/or the United States for multiple indications, including type 2 diabetes mellitus in adults, overweight/obesity, chronic kidney disease, and metabolic dysfunction-associated steatohepatitis (MASH).
In March 2025, Novo Nordisk acquired global rights (excluding mainland China, Hong Kong SAR, Macau SAR, and Taiwan) to develop, manufacture, and commercialize UBT251 for $2 billion. TUL retained rights to UBT251 in mainland China, Hong Kong SAR, Macau SAR, and Taiwan.
In February 2026, TUL announced positive results from a Phase II clinical study of UBT251 in Chinese overweight/obese patients. The related findings were presented as a Late-Breaking Abstract (LBA) at the 2026 ADA Annual Meeting. The study data showed significant weight loss across all UBT251 dose groups. After 24 weeks of treatment, the mean change in body weight from baseline in the treatment groups was up to -19.7% (-17.5 kg), compared with -2.0% (-1.6 kg) in the placebo group. Additionally, the proportion of participants achieving a ≥5% reduction in body weight from baseline was up to 98.1% in the UBT251 dose groups; the proportion achieving ≥10% reduction was up to 89.8%, and the proportion achieving ≥20% reduction was up to 48.4%.
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