How much does Entresto (Sacubitril Valsartan Sodium Tablets) Cost& price without insurance in China?
Entresto® is the commercial brand name of Sacubitril Valsartan Sodium Tablets, developed by Novartis. It is an oral dual-acting cardiovascular agent combining neprilysin inhibitor and angiotensin II receptor antagonist. It enhances endogenous natriuretic peptide levels while blocking angiotensin receptors, exerting vasodilation, diuretic and cardiac remodeling reversal effects to relieve heart failure burden.
Main Indications
Treatment of chronic heart failure with reduced ejection fraction in adult patients to reduce cardiovascular death and heart failure hospitalization risks.
Clinical Research
Global large-scale pivotal trials fully validated its long-term cardiac protective efficacy for heart failure populations;
Phase III registration trials confirmed significant reduction of all-cause cardiovascular mortality and repeated hospitalization rates versus single ARB therapy;
Cardiac ultrasound observational studies demonstrated improved left ventricular ejection fraction and reversed adverse myocardial remodeling after long-term oral administration;
Dose titration comparative research identified optimal once-daily dosing with balanced hypotensive safety and cardiac benefits;
Long-term follow-up trials verified stable sustained heart function improvement and controllable overall adverse reaction spectrum.
Common Side Effects
Common mild adverse reactions: Hypotension, dizziness, hyperkalemia, fatigue and renal function transient fluctuation;
Laboratory abnormalities: Transient elevation of serum potassium and serum creatinine;
Severe but uncommon risks: Severe hypotension, acute kidney injury, angioedema and hyperkalemia crisis.
Approval Status in China
Entresto® (specification 100mg per tablet, 14 tablets per box) obtained marketing approval in China in 2017. It is an oral prescription heart failure therapeutic drug included in China’s Category B medical insurance catalogue.
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