Sikaite Acetyllevocarnitine Hydrochloride Tablets

1. Indications and Usage
Diabetic Peripheral Neuropathy: Treatment of sensory abnormalities caused by diabetic peripheral neuropathy.
2. Dosage and Administration
Route of Administration: Oral administration ONLY.
Recommended Dosage: Adults typically take 250-500 mg per dose, 2-3 times daily.
Critical Administration Instructions:
Timing: Should be taken after meals.
Contraindications: As an acidic drug, it must not be mixed or administered with alkaline drugs.
3. Mechanism of Action
Neuroprotection: Promotes mitochondrial uptake of acetyl-CoA in the process of fatty acid oxidation, increases acetylcholine production, and stimulates protein and membrane phospholipid synthesis.
Neuronal Repair: Stabilizes cell membrane fluididity and provides substrates for cellular energy production, thereby preventing excessive neuronal death and helping in nerve cell repair and regeneration.
4. Safety and Warnings
Hypersensitivity: Contraindicated in patients with known hypersensitivity to acetyllevocarnitine or any excipients.
Pregnancy and Lactation: Although no obvious fetal effects have been found in animal studies, use with caution during the first trimester of pregnancy and lactation.
Dizziness: Dizziness may occur; exercise caution when operating machinery or driving.
5. Adverse Reactions and Clinical Research
Most Common Adverse Reactions: Gastrointestinal symptoms (hiccups, nausea, abdominal distension, dizziness, weight loss) and mild elevation of liver function tests.
Other Adverse Reactions: Rare reports of mild agitation, which can be eliminated by dose reduction.
Clinical Research Highlights: Clinical data indicate that most adverse reactions are mild. The drug has no risk of addiction or dependence.
6. Drug Interactions
Alkaline Drugs: As an acidic drug, it cannot be compounded or administered with alkaline drugs.
Other Drugs: Drug interactions are currently unclear.
7. Pharmaceutical Information
Chemical Composition: Active Ingredient: Acetyllevocarnitine Hydrochloride.
Appearance: White or off-white tablets.
Packaging: Aluminum-plastic blister packaging.
Storage: Store sealed at a temperature not exceeding 25°C.