- Indications and Usage Cardiovascular Secondary Prevention: Indicated for the secondary prevention of unstable angina, acute myocardial infarction, and ischemic cerebrovascular disorders in patients requiring aspirin for antiplatelet effects but who cannot tolerate gastrointestinal reactions to conventional aspirin formulations.
- Dosage and Administration Recommended Dosage: Typically taken orally once daily, one tablet. Dose adjustments may be made based on clinical indications, but it should not exceed four tablets at a time. Administration: The tablets should be swallowed with water. Special Populations: Not recommended for low-birth-weight infants, newborns, or those unable to swallow tablets. Contraindicated in pediatric patients under 15 years old with varicella or influenza due to the risk of Reye’s syndrome.
- Mechanism of Action Antiplatelet Effect: The aspirin component irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, blocking thromboxane A2 synthesis and inhibiting platelet aggregation. Gastroprotection: The aluminum hydroxide and heavy magnesium carbonate components neutralize excess gastric acid and form a physical protective film over the gastric mucosa, reducing aspirin-induced gastric injury.
- Safety and Warnings Bleeding Risk: May cause intracranial or gastrointestinal hemorrhage. Patients should be monitored for signs of bleeding, especially those with a history of ulcers. Hypersensitivity Asthma: Contraindicated in patients with a history of asthma, urticaria, or allergic reactions after taking nonsteroidal anti-inflammatory drugs (NSAIDs). Hepatic and Renal Impairment: Use with caution in patients with severe liver or kidney dysfunction, as aspirin metabolism and excretion may be impaired.
- Adverse Reactions and Clinical Research Gastrointestinal Disorders: The most common adverse events include dyspepsia, abdominal pain, vomiting, and gastrointestinal ulcers, though the incidence is significantly lower compared to conventional aspirin. Hematologic Abnormalities: Rare cases of thrombocytopenia, leukopenia, or agranulocytosis have been reported. Clinical Significance: Clinical studies demonstrate that the addition of antacids to aspirin significantly reduces gastric mucosal injury without compromising the antiplatelet efficacy of aspirin.
- Drug Interactions Corticosteroids and Other NSAIDs: Concomitant use with corticosteroids or other NSAIDs may increase the risk of gastrointestinal ulcers or bleeding. Anticoagulants: Increased risk of bleeding when combined with warfarin, heparin, or other anticoagulants. Methotrexate: Aspirin may decrease the renal clearance of methotrexate, increasing its toxicity.
- Pharmaceutical Information Active Ingredients: Aspirin, Heavy Magnesium Carbonate, and Dihydroxyaluminum Aminoacetate. Dosage Forms: Pale yellow tablets, typically available in 12, 15, 24, or 30 tablets per pack. Storage: Store in a dry place, protected from light and moisture.
Aside Aluminum Magnesium Aspirin Tablets (II)
Brand Name: 阿斯德 ®（Aside®）
Generic Name: Aluminum Magnesium Aspirin
Strength: 81 mg per tablet, 30 tablets per box
Manufacturer: Shandong China Health Bridge Pharmaceutical Co., Ltd.
Marketing Authorization Holder: Shandong China Health Bridge Pharmaceutical Co., Ltd.
Approval Date in China: August 25, 2017
Registration Number: 国药准字H20174102
Storage: Seal tightly, store below 25°C, protect from light and moisture. Refer to the full package insert for detailed storage specifications.
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