Tamiflu Oseltamivir Phosphate Capsules

1. Indications and Usage
Treatment: Treatment of influenza in patients 1 year and older.
Prophylaxis: Prophylaxis of influenza in patients 13 years and older.
2. Dosage and Administration
Treatment: The recommended oral dosage for adults and adolescents (13 years and older) is 75 mg twice daily for 5 days.
Prophylaxis: The recommended oral dosage for adults and adolescents (13 years and older) is 75 mg once daily for at least 6 weeks.
Renal Impairment: Dosage adjustment is required for patients with creatinine clearance less than 30 mL/min.
Administration: Oseltamivir phosphate can be taken with or without food.
3. Mechanism of Action
Neuraminidase Inhibition: Oseltamivir phosphate is an orally active prodrug that is converted in vivo to oseltamivir carboxylate.
Viral Inhibition: Oseltamivir carboxylate is a selective inhibitor of influenza virus neuraminidase, inhibiting the release of virions from infected cells and subsequent spread of infection.
4. Safety and Warnings
Neuropsychiatric Events: Abnormal behavior has been reported, particularly in pediatric patients.
Severe Renal Impairment: Use with caution in patients with severe renal impairment; dose adjustment is necessary.
Hypersensitivity: Serious skin reactions have been reported.
5. Adverse Reactions and Clinical Research
Common: The most common adverse reactions are nausea and vomiting.
Clinical Research: Clinical trials have demonstrated efficacy in reducing the duration of influenza symptoms when administered within 48 hours of symptom onset.
6. Drug Interactions
Vaccines: Live attenuated intranasal influenza vaccine should not be used within 2 weeks before or 48 hours after oseltamivir phosphate administration.
Probenecid: Probenecid decreases the renal clearance of oseltamivir carboxylate, but dose adjustment is not required due to the wide therapeutic margin.
7. Pharmaceutical Information
Active Ingredient: Oseltamivir Phosphate.
Appearance: Hard gelatin capsules containing white to off-white powder.
Storage: Store in a well-closed container, protected from moisture.