Trittico® is the commercial brand name of Trazodone Hydrochloride Sustained‑release Tablets, an oral serotonin‑modulating antidepressant developed by Angelini Pharma of Italy. It acts on multiple serotonin receptors in the central nervous system to regulate serotonin transmission and exert antidepressant, anxiolytic and sedative‑hypnotic effects.
Main Indications
Treatment of depressive disorders;
Treatment of depression accompanied by anxiety symptoms;
Improvement of sleep disturbance associated with depression.
Clinical Research
Global multicenter double‑blind, placebo‑controlled trials demonstrated that Trittico® can effectively improve core depressive symptoms assessed by the HAMD‑17 scale;
Compared with immediate‑release trazodone tablets, this sustained‑release formulation delivers more stable plasma drug concentration and reduces peak‑related adverse reactions;
Domestic multicenter clinical trials in China showed consistent efficacy and safety results between Chinese patients and global trial populations.
Common Side Effects
Serious risks: suicidal ideation and behaviours (especially in young adults), orthostatic hypotension, QT‑interval prolongation;
Common mild adverse reactions: drowsiness, dizziness, dry mouth, headache, nausea, fatigue, palpitations, blurred vision and allergic reactions.
Approval Status in China
Original drug Trittico® (Trazodone Hydrochloride Sustained‑release Tablets) was officially approved for marketing in China in 2020, with specifications of 75 mg and 150 mg. It is currently a prescription drug included in China’s category B medical insurance.
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