Tapros® is the commercial brand name of Tafluprost Eye Drops, a prostaglandin F2α analogue topical ophthalmic hypotensive drug developed by Santen Pharmaceutical Co., Ltd. It increases uveoscleral aqueous humor outflow to reduce intraocular pressure for long-term glaucoma management.
Main Indications
Reduction of elevated intraocular pressure in patients with open-angle glaucoma;
Reduction of elevated intraocular pressure in patients with ocular hypertension.
Clinical Research
Global multicenter phase III pivotal trials verified that once-nightly topical tafluprost provides stable 24-hour intraocular pressure lowering effect with durable long-term efficacy;
Head-to-head clinical trials against other prostaglandin eye drops demonstrated favorable ocular surface tolerance and less conjunctival hyperemia side effects;
Domestic registration clinical trials in Chinese glaucoma patients showed consistent intraocular pressure-lowering efficacy and safety data matching global trial results.
Common Side Effects
Severe adverse reactions: Severe ocular allergic reaction, macular edema, iris pigmentation excessive deposition, systemic hypersensitivity reaction (rare but severe);
Common mild adverse reactions: Conjunctival congestion, eyelash thickening/lengthening, iris darkening, ocular stinging, dry eye, headache, eyelid pigmentation.
Approval Status in China
Original drug Tapros® (Tafluprost Eye Drops, specification: 2.5ml:37.5μg) obtained imported drug marketing approval in China in 2015. It is a prescription ophthalmic drug included in China’s category B medical insurance catalogue.
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