Essentiale Polyene Phosphatidylcholine Capsules

1. Indications and Usage
Liver Disorders: Supportive treatment of various types of liver damage, including fatty liver, hepatitis, and liver intoxication.
Specific Conditions: Indicated for non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and as adjunctive therapy in cirrhosis.
2. Dosage and Administration
Adults: The usual dosage is 2 capsules (1.08 g) taken 3 times daily.
Administration: Capsules should be swallowed with a little water and not chewed, as they are designed to be released in the intestine.
Duration: The duration of treatment depends on the severity of the disease and the clinical course.
3. Mechanism of Action
Membrane Repair: Polyene phosphatidylcholine selectively binds to the phospholipid-deficient areas of damaged hepatocyte membranes.
Hepatoprotection: By restoring the integrity of the cell membrane, it helps prevent the excretion of liver enzymes (aminotransferases) and supports liver cell regeneration.
4. Safety and Warnings
Contraindications: Contraindicated in patients with known hypersensitivity to the drug, soy, or peanut derivatives.
Special Populations: Safety and efficacy in children and adolescents under 12 years of age have not been fully established. Use with caution in pregnant or breastfeeding women.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: Occasionally, gastrointestinal discomfort or mild skin allergies (e.g., rash, pruritus) may occur.
Hypersensitivity: Severe allergic reactions are rare but possible in patients with soy or peanut allergies.
6. Drug Interactions
Interaction Profile: No significant drug interactions have been reported. It is generally compatible with other hepatoprotective agents.
7. Pharmaceutical Information
Active Ingredient: Polyene Phosphatidylcholine.
Strength: Each capsule typically contains 0.54 g of highly purified polyene phosphatidylcholine (equivalent to 263 mg of phosphatidylcholine).
Appearance: Hard gelatin capsules, usually with a white or off-white powder inside.
Storage: Store in a dry place, protected from light, at temperatures not exceeding 25°C.