Zhengchangsheng Bacillus Licheniformis Live Bacteria Capsules

1. Indications and Usage
Intestinal Flora Imbalance: Indicated for the treatment of diarrhea, abdominal distension, and dyspepsia caused by intestinal flora disorders.
Secondary Diarrhea: Used as an adjunctive therapy for acute or chronic diarrhea associated with infections or antibiotic use.
2. Dosage and Administration
Adults: The usual dosage is 2 capsules per dose, 3 times daily.
Children: The dosage is typically 1 capsule per dose, 3 times daily.
Administration: Capsules should be swallowed with warm water or mixed with lukewarm food (below 40°C).
Antibiotic Timing: Should be taken at least 2 hours apart from antibiotic therapy to prevent the live bacteria from being killed by the drug.
3. Mechanism of Action
Flora Regulation: Bacillus licheniformis colonizes the intestine and competes with pathogenic bacteria for nutrients and adhesion sites, inhibiting their growth.
Metabolic Activity: The bacteria produce enzymes and metabolic products that help digest food, enhance nutrient absorption, and promote the synthesis of B-group vitamins.
4. Safety and Warnings
Contraindications: Contraindicated in patients with known hypersensitivity to the drug or its components.
Temperature Control: The drug contains live bacteria and must not be taken with hot water or food, as high temperatures will kill the viable strains.
Antibiotic Interaction: Avoid concurrent administration with bactericidal antibiotics; if antibiotics are necessary, a significant time interval should be maintained.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: The drug is generally well-tolerated. Occasionally, mild gastrointestinal symptoms such as increased flatulence or abdominal discomfort may occur during the initial phase of treatment.
Rare Effects: No serious adverse reactions have been commonly reported in clinical studies.
6. Drug Interactions
Antibiotics: Bactericidal antibiotics (e.g., penicillins, cephalosporins) may kill the administered bacteria. Bacteriostatic antibiotics (e.g., tetracyclines, chloramphenicol) may inhibit their activity.
Adsorbents: Medications that adsorb toxins (e.g., activated charcoal, bismuth preparations) may reduce the efficacy of the probiotic if taken simultaneously.
7. Pharmaceutical Information
Active Ingredient: Bacillus Licheniformis (live spores).
Strength: Typically 250 mg per capsule (containing a specified number of viable colony-forming units).
Appearance: Hard gelatin capsules containing off-white or light yellow powder.
Storage: Keep in a dry and cool place (usually below 20-25°C), protected from light and moisture.