Saiweijian® is the commercial brand name of Raltitrexed for Injection, a folate antimetabolite cytotoxic agent developed by Chia Tai Tianqing. It inhibits thymidylate synthase, disrupting DNA synthesis and thereby suppressing tumor cell proliferation.
Main Indications
For the treatment of advanced colorectal cancer in adult patients who cannot tolerate fluorouracil-based chemotherapy.
Clinical Research
The global pivotal phase III trials demonstrated that raltitrexed achieved comparable anti-tumor efficacy to 5-FU/leucovorin regimens in advanced colorectal cancer, with a more convenient administration schedule;
Domestic clinical study verified its efficacy and safety profile in Chinese patients with metastatic colorectal cancer;
Subsequent researches explored its combination use with other chemotherapeutic agents and targeted therapies.
Common Side Effects
Severe but important risks: Severe myelosuppression, severe gastrointestinal toxicity, hepatic injury;
Common mild adverse reactions: Fatigue, nausea, vomiting, diarrhea, anorexia, stomatitis and rash.
Approval Status in China
Original drug Saiweijian® (Raltitrexed for Injection, specification:2mg per vial) was officially approved for marketing in China. It is currently a prescription cytotoxic anticancer drug.
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