Futhan® is the commercial brand name of Nafamostat Mesilate for Injection, a synthetic serine protease inhibitor. It blocks a wide range of proteases such as trypsin, kallikrein, thrombin and plasmin, thereby restraining excessive inflammatory response and abnormal coagulation activation.
Main Indications
Treatment of acute pancreatitis, and improvement of disseminated intravascular coagulation (DIC) in adult patients.
Clinical Research
Global clinical trials demonstrated that nafamostat mesilate can decrease pancreatic enzyme levels and alleviate clinical manifestations in acute pancreatitis;
Multiple studies verified its ability to improve coagulation parameters and reduce mortality in patients with DIC from different triggers;
Clinical evidence also explored its use in extracorporeal circulation to prevent clotting, with attention paid to bleeding risk.
Common Side Effects
Severe but important risks: Hemorrhagic tendency, severe hypersensitivity, anaphylactic shock and liver injury;
Common mild adverse reactions: Injection site irritation, nausea, vomiting, diarrhea, thrombocytopenia and skin pruritus.
Approval Status in China
Futhan® (Nafamostat Mesilate for Injection, specification:10mg per vial) was officially approved for marketing in China. It is currently a prescription protease inhibitor.
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