Zepuping® is the commercial brand name of Gecacitinib Hydrochloride Tablets, a selective JAK inhibitor. It inhibits Janus kinase family enzymes to block multiple cytokine signaling pathways and reduce inflammatory responses.
Main Indications
For the treatment of adult patients with moderate to severe atopic dermatitis who are candidates for systemic therapy.
Clinical Research
Clinical trials demonstrated that gecacitinib significantly improves skin lesion clearance and relieves pruritus in patients with moderate-to-severe atopic dermatitis. Rapid symptom improvement can be observed as early as week 2, with a generally manageable adverse event profile.
Common Side Effects
Systemic reactions: upper respiratory tract infection, headache;
Common mild adverse reactions: nausea, elevated blood lipids. Rare serious adverse events: serious infection, thromboembolic events.
Approval Status in China
Original drug Zepuping® (Gecacitinib Hydrochloride Tablets) was officially approved for marketing in China in 2024, with the specification of 50mg. It is currently a prescription immunomodulatory drug.
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