Wellbutrin XR® is the overseas reference original brand and has NOT been approved for marketing in mainland China. The domestic generic product made by Apeloa is Yuandakang®. It is an aminoketone antidepressant. It inhibits the reuptake of norepinephrine and dopamine to regulate monoamine neurotransmitters in the central nervous system.
Main Indications
For the treatment of major depressive disorder in adults.
Clinical Research
Global phase 3 clinical trials of Wellbutrin XR demonstrated that once-daily bupropion XR effectively improves depressive symptoms. Unlike SSRIs, it has minimal impact on sexual function. The extended-release formulation reduces peak plasma concentration, which lowers seizure risk compared with immediate-release tablets.
Common Side Effects
Systemic reactions: insomnia, dry mouth;
Common mild adverse reactions: headache, anxiety, nausea, tremor. Rare serious adverse events: seizures, hypersensitivity reactions.
Approval Status in China
This domestic generic drug, marketed under brand name Yuandakang® (reference brand name Wellbutrin XR®), was officially approved for marketing in China in 2024, with the specification of 150mg, 30 tablets per bottle. It is currently a prescription psychiatric drug.
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