CALQUENCE® is the commercial brand name of Acalabrutinib Capsules, a highly selective, irreversible second-generation Bruton tyrosine kinase (BTK) inhibitor developed by AstraZeneca. It exerts anti-tumor activity by covalently binding to BTK, thereby inhibiting B-cell receptor signaling and blocking the proliferation…
IBRANCE® is the commercial brand name of Palbociclib Capsules, a first-in-class, orally active cyclin-dependent kinase 4/6 (CDK4/6) inhibitor developed by Pfizer. It exerts anti-tumor activity by selectively inhibiting CDK4/6, thereby blocking the phosphorylation of the retinoblastoma (Rb) protein, arresting the…
KOSELUGO® is the commercial brand name of Selumetinib Hydrogen Sulfate Capsules, an oral, selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor developed by AstraZeneca. It exerts its therapeutic effect by blocking the abnormal activation of the RAS/RAF/MEK/ERK signaling pathway, thereby…
ZYKADIA® is the commercial brand name of Ceritinib Capsules, a second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor developed by Novartis. It exerts anti-tumor activity by selectively inhibiting the kinase activity of ALK, thereby blocking downstream signaling pathways and suppressing…
XALKORI® is the commercial brand name of Crizotinib Capsules, a first-generation anaplastic lymphoma kinase (ALK) and c-MET/ROS1 tyrosine kinase inhibitor developed by Pfizer. It exerts anti-tumor activity by selectively inhibiting the kinase activity of ALK, ROS1 and c-MET, thereby blocking…
Tafinlar® is the commercial brand name of Dabrafenib Mesylate Capsules, a selective BRAF kinase inhibitor developed by Novartis. It exerts anti-tumor activity by specifically inhibiting the mutated BRAF protein (BRAF V600E/V600K), thereby blocking the aberrant activation of the MAPK signaling…
Tasigna® is the commercial brand name of Nilotinib Capsules, a second-generation tyrosine kinase inhibitor (TKI) developed by Novartis. It exerts its anti-tumor activity by selectively inhibiting the BCR-ABL tyrosine kinase, thereby suppressing the proliferation of BCR-ABL-positive leukemic cells. Main IndicationsTreatment…
Ruibikang® is the commercial brand name of Oteseconazole Capsules, a novel, orally active azole antifungal agent developed by Hengrui Medicine. It exerts antifungal effects by inhibiting fungal cytochrome P450 14α-demethylase (CYP51), thereby blocking ergosterol synthesis and disrupting the fungal cell…
CRESEMBA® is the commercial brand name of Isavuconazonium Sulfate Capsules, a novel triazole antifungal agent developed by Basilea Pharmaceutica Deutschland GmbH. As a prodrug, it is rapidly converted in vivo to isavuconazole, which exerts its antifungal activity by inhibiting the…
NEFECON® is the commercial brand name of Budesonide Enteric Capsules, a targeted, delayed-release formulation of the synthetic corticosteroid budesonide developed by Everest Medicines. It is designed to deliver budesonide locally to the ileum, modulating the mucosal immune response to reduce…