Rinvoq® is the commercial brand name of Upadacitinib Sustained-release Tablets, an orally active selective Janus kinase (JAK) inhibitor developed by AbbVie. It preferentially inhibits JAK1 to block the signal transduction of multiple pro-inflammatory cytokines and suppress abnormal inflammatory immune responses.
Main Indications
Treatment of adult patients with moderately to severely active rheumatoid arthritis who have an inadequate response or intolerance to one or more conventional synthetic disease-modifying antirheumatic drugs;
Treatment of adult patients with moderately to severely active psoriatic arthritis;
Treatment of adult patients with moderately to severely active ankylosing spondylitis;
Treatment of adult patients with moderately to severely active ulcerative colitis.
Clinical Research
Global multicenter phase III trials demonstrated that upadacitinib achieves significant improvements in joint symptoms, physical function and inflammatory biomarkers among patients with rheumatic immune diseases;
Long-term extension trials confirmed sustained clinical efficacy and a predictable safety profile during continuous oral administration;
Clinical trials conducted in Chinese patient cohorts verified consistent therapeutic effects and comparable tolerability with global study populations.
Common Side Effects
Severe but important risks: Serious infections, thromboembolic events, elevated risk of malignancy, hepatic function abnormality, lipid metabolism disorder;
Common mild adverse reactions: Upper respiratory tract infection, nausea, cough, fever, headache and acne.
Approval Status in China
Original drug Rinvoq® (Upadacitinib Sustained-release Tablets) was officially approved for marketing in China in 2022, with the specification of 15 mg per tablet, 28 tablets per box. It is currently a prescription drug included in China’s Category B medical insurance catalogue.
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