How much does HIBOR (Bemiparin Sodium Injection) Cost& price without insurance in China?
HIBOR® is the commercial brand name of Bemiparin Sodium Injection, developed and manufactured by Laboratorios Farmacéuticos ROVI, S.A. It belongs to low molecular weight heparin. It exerts anti-Xa and weak anti-IIa effects to suppress platelet aggregation and coagulation factor activity, achieving stable anticoagulation through subcutaneous administration with low bleeding risk.
Main Indications
Prophylaxis of venous thromboembolism in surgical patients and bedridden medical patients;
Treatment of established deep vein thrombosis with or without pulmonary embolism;
Anticoagulation during hemodialysis.
Clinical Research
Multicenter global clinical trials verified its anticoagulation efficacy and safety. Thromboembolism prevention trials proved it effectively reduces the incidence of postoperative venous thrombosis with convenient once-daily dosing. Therapeutic anticoagulation trials showed non-inferior efficacy against standard low molecular weight heparins for deep vein thrombosis treatment. Hemodialysis observational studies demonstrated stable anticoagulant performance during extracorporeal circulation. Tolerability research reflected mild local injection reactions as the main mild adverse event, with low overall bleeding incidence. Long-term prophylaxis trials confirmed sustained reliable safety profile for prolonged preventive use.
Common Side Effects
Common mild adverse reactions: Local injection site bruising, mild pain, slight thrombocytopenia and transient elevated liver enzymes;
Laboratory abnormalities: Transient mild increase in liver transaminases;
Severe but uncommon risks: Severe hemorrhage, heparin-induced thrombocytopenia, hypersensitivity and skin necrosis at injection site.
Approval Status in China
HIBOR® (specification 0.2ml:3500 IU anti-Xa, 10 pre-filled syringes per box) obtained marketing approval in China in 2019. It is a subcutaneous injectable prescription anticoagulant drug covered by China’s Category B medical insurance catalogue.
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