How much does KOSELUGO (Selumetinib Hydrogen Sulfate Capsules) Cost& price without insurance in China?
KOSELUGO® is the commercial brand name of Selumetinib Hydrogen Sulfate Capsules, an oral, selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor developed by AstraZeneca. It exerts its therapeutic effect by blocking the abnormal activation of the RAS/RAF/MEK/ERK signaling pathway, thereby inhibiting the proliferation of neurofibromas in patients with neurofibromatosis type 1 (NF1).
Main Indications
Treatment of pediatric patients aged 3 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN).
Common Side Effects
Common adverse reactions: Vomiting, rash, diarrhea, abdominal pain, nausea, fatigue, musculoskeletal pain, fever, dry skin, and pruritus.
Laboratory abnormalities: Decreased ejection fraction, elevated creatine phosphokinase, increased alanine aminotransferase (ALT), and increased aspartate aminotransferase (AST).
Severe but manageable risks: Cardiomyopathy (decreased left ventricular ejection fraction), ocular toxicities (retinal vein occlusion, retinal pigment epithelial detachment), severe diarrhea, and increased risk of infection.
Approval Status in China
KOSELUGO® (Selumetinib Hydrogen Sulfate Capsules, 10mg and 25mg) was officially approved for marketing in China in May 2023 and launched in September 2023. It is currently a prescription drug included in China’s Category B medical insurance.
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