How much does VITRAKVI (Larotrectinib Sulfate Capsules) Cost& price without insurance in China?
VITRAKVI® is the commercial brand name of Larotrectinib Sulfate Capsules, a highly selective tropomyosin receptor kinase (TRK) inhibitor developed by Bayer. It exerts anti-tumor activity by specifically inhibiting the kinase activity of tropomyosin receptor kinases (TRKA, TRKB, TRKC) encoded by NTRK gene fusions, thereby blocking downstream signaling pathways and suppressing the proliferation and survival of tumor cells harboring these fusions.
Main Indications
Treatment of adult and pediatric patients with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation, who have metastatic disease or are likely to progress following surgery, and who have no satisfactory alternative treatments or whose disease progressed following prior treatment.
Common Side Effects
Common adverse reactions: Fatigue, nausea, dizziness, vomiting, anemia, constipation, diarrhea, cough, peripheral edema, and abdominal pain.
Laboratory abnormalities: Decreased neutrophil count, decreased lymphocyte count, decreased hemoglobin, and increased transaminases.
Severe but manageable risks: Central nervous system adverse reactions (including dizziness, cognitive impairment, and mood disorders), hepatotoxicity, and skeletal fractures.
Approval Status in China
VITRAKVI® (Larotrectinib Sulfate Capsules, 100mg) was officially approved for marketing in China in April 2022. It is currently a prescription drug included in China’s Category B medical insurance.
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