Changyunkang Clostridium Butyricum Bifidobacterium Live Combined Capsules

1. Indications and Usage
Intestinal Flora Imbalance: Indicated for the treatment of diarrhea, abdominal bloating, and dyspepsia caused by intestinal flora disorders.
Acute and Chronic Diarrhea: Used as an adjunctive therapy for acute infectious diarrhea and chronic diarrhea.
Pediatric Indications: Also indicated for intestinal flora imbalance and diarrhea in infants and children.
2. Dosage and Administration
Adults: The usual dosage is 2 capsules per dose, 3 times daily.
Children: The dosage is typically 1 capsule per dose, 3 times daily (or as directed by a physician).
Administration: Capsules should be swallowed with warm water or lukewarm boiled water (below 40°C).
Antibiotic Timing: Should be taken at least 2 hours apart from antibiotic therapy to prevent the live bacteria from being killed.
3. Mechanism of Action
Synergistic Regulation: Clostridium butyricum produces butyric acid to repair the intestinal mucosal barrier, while Bifidobacterium helps acidify the gut and inhibit pathogens.
Anaerobic Environment: Both are strict or facultative anaerobes that consume oxygen in the gut, creating a favorable environment for indigenous beneficial bacteria.
Nutrient Synthesis: The bacteria promote the synthesis of B-group vitamins and enhance the absorption of nutrients and calcium.
4. Safety and Warnings
Temperature Control: The drug contains live bacteria and must be taken with water below 40°C to prevent the death of viable spores and bacteria.
Antibiotic Interaction: If antibiotic therapy is necessary, a significant time interval (at least 2 hours) should be maintained.
Hypersensitivity: Contraindicated in patients with known hypersensitivity to the drug or its excipients.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: The drug is generally well-tolerated. Occasionally, mild gastrointestinal symptoms such as abdominal discomfort or increased flatulence may occur.
Rare Effects: No serious adverse reactions have been commonly reported in clinical studies.
6. Drug Interactions
Antibiotics: Bactericidal and bacteriostatic antibiotics may inhibit the activity or kill the administered bacteria.
Adsorbents: Medications that adsorb toxins (e.g., activated charcoal, bismuth preparations) may reduce the efficacy of the probiotic if taken simultaneously.
7. Pharmaceutical Information
Active Ingredients: Clostridium butyricum and Bifidobacterium (live spores and bacteria).
Strength: Typically 250 mg or a specified number of CFU (Colony-Forming Units) per capsule.
Appearance: Hard gelatin capsules containing light yellow or off-white powder.
Storage: Keep in a dry and cool place, protected from light and moisture.