Siliankang Live Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets

Brand Name: 思连康®(Siliankang®)
Generic Name: Live Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus
Strength: 0.5 g per tablet
Manufacturer: Hangzhou Yuanda Biopharmaceutical Co., Ltd.
Marketing Authorization Holder: Hangzhou Yuanda Biopharmaceutical Co., Ltd.
Approval Date in China: 2006‑04‑12
Registration Number: National Drug Approval No. S20060010
Storage: Store sealed at 2‑8℃, protected from light

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1. Indications and Usage
Intestinal Dysfunction: Indicated for the treatment of intestinal dysfunction and acute or chronic diarrhea caused by intestinal flora imbalance.
Antibiotic-Associated Diarrhea: Used to restore the normal microecological environment in the gastrointestinal tract.
2. Dosage and Administration
Adults: The usual dosage is 4 tablets per dose, 3 times daily.
Children: The dosage varies by age (e.g., 1–5 years: 2 tablets; <1 year: 1 tablet), 2–3 times daily.
Administration: Tablets should be swallowed with warm water or warm milk (below 40°C). For infants, tablets can be crushed and dissolved in warm milk.
3. Mechanism of Action
Flora Regulation: The combination of Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus cereus directly supplements normal physiological bacteria to regulate intestinal flora.
Biological Barrier: It forms a biological barrier in the intestine, lowering pH to inhibit the growth of putrefactive and potentially harmful pathogenic bacteria.
4. Safety and Warnings
Temperature Control: As a live bacterial preparation, it must not be exposed to high temperatures.
Storage: Must be stored in a refrigerator at 2°C to 8°C, protected from light and moisture.
Hypersensitivity: Contraindicated in patients with known hypersensitivity to the drug or its excipients.
5. Adverse Reactions and Clinical Research
Common Adverse Reactions: No adverse reactions have been observed in clinical studies.
Management: The drug is generally well-tolerated, and no specific management is typically required.
6. Drug Interactions
Antibiotics: Concurrent use with antibacterial drugs may weaken the efficacy. They should be taken separately with a significant time interval.
Antacids and Adsorbents: Antacids, bismuth preparations, tannic acid, and activated charcoal can inhibit, adsorb, or kill the live bacteria.
7. Pharmaceutical Information
Active Ingredients: Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus cereus.
Strength: Typically 0.5 g per tablet.
Appearance: White or off-white tablets, sometimes with pinkish spots of bacteria.
Storage: Transport by cold chain, store in a dry and cool place (2°C to 8°C), protected from light.

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