How much does Praluent (Alirocumab Injection) Cost& price without insurance in China?
Praluent® is the commercial brand name of Alirocumab Injection, developed by Sanofi. It is a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9). It blocks the binding of PCSK9 to low-density lipoprotein receptors, increasing hepatic LDL receptor quantity and significantly reducing circulating low-density lipoprotein cholesterol levels.
Main Indications
Adjunct therapy to diet and statins for adults with primary hypercholesterolemia to lower LDL-C;
Secondary cardiovascular event risk reduction in adult patients with established atherosclerotic cardiovascular disease.
Clinical Research
Global multicenter phase III trials fully validated its potent lipid-lowering efficacy for hyperlipidemic patients;
Lipid control trials confirmed sustained profound LDL-C reduction when combined with statin therapy;
Cardiovascular outcome studies demonstrated significant decline in myocardial infarction, stroke and cardiovascular death risks;
Subcutaneous administration observational research showed favorable long-term patient adherence with biweekly dosing;
Long-term safety follow-up trials verified low severe adverse event incidence and controllable overall safety spectrum.
Common Side Effects
Common mild adverse reactions: Injection site erythema, pruritus, headache, myalgia and influenza-like symptoms;
Laboratory abnormalities: Rare transient mild elevation of liver enzymes;
Severe but uncommon risks: Severe hypersensitivity reactions, myopathy and thrombocytopenia.
Approval Status in China
Praluent® (specification 1.0ml:75mg per pre-filled pen, 2 pens per box) obtained marketing approval in China in 2019. It is a subcutaneous injectable prescription lipid-regulating biologic drug included in China’s Category B medical insurance catalogue.
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