How much does Somatuline Autogel (Lanreotide Acetate Sustained-release Injection) Cost& price without insurance in China?
Somatuline Autogel® is the commercial brand name of Lanreotide Acetate Sustained-release Injection, developed by Ipsen. It is a pre-filled long-acting gel-type somatostatin analog. It suppresses excess secretion of growth hormone, IGF-1 and gastrointestinal hormones, relieves clinical symptoms of hormone-secreting tumors and slows tumor progression with a single deep subcutaneous injection every 28 days.
Main Indications
Long-term symptom control for adult acromegaly patients who respond to short-acting somatostatin analogues;
Symptom relief and tumor growth inhibition for unresectable well-differentiated gastroenteropancreatic neuroendocrine tumors;
Treatment of refractory flushing and severe diarrhea caused by carcinoid syndrome.
Clinical Research
Global multicenter pivotal trials fully validated its sustained hormone suppression efficacy for patients with acromegaly and neuroendocrine neoplasms;
Phase III registration trials confirmed stable reduction of growth hormone and IGF-1 levels under monthly single-dose administration;
GEP-NET cohort observational studies demonstrated durable relief of carcinoid syndrome manifestations and delayed tumor progression;
Dose-finding comparative research verified balanced therapeutic effect and local injection tolerability of the 90mg monthly regimen;
Long-term safety follow-up trials confirmed mild gastrointestinal and gallbladder-related adverse reactions are manageable during chronic maintenance therapy.
Common Side Effects
Common mild adverse reactions: Injection site pain and induration, abdominal distension, diarrhea, nausea and gallstone formation;
Laboratory abnormalities: Rare transient blood glucose fluctuation and mild elevation of liver transaminases;
Severe but uncommon risks: Severe systemic hypersensitivity, bradycardia, biliary obstruction and severe hypoglycemia.
Approval Status in China
Somatuline Autogel® (specification 90mg per pre-filled syringe, 1 syringe per box) obtained marketing approval in China in 2019. It is a deep subcutaneous injectable prescription drug for acromegaly and neuroendocrine tumors, included in China’s Category B medical insurance catalogue.
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